人脐带间充质干细胞在膝骨关节炎治疗中的研究进展  

Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis

作　　者：龚瑾 张进进 陈立力[2] 王辉 邢颜超 GONG Jin;ZHANG Jinjin;CHEN Lili;WANG Hui;XING Yanchao(School of Postgraduates,Xinjiang Medical University,Urumqi 830054,China;Department of Blood Transfusion,General Hospital of Xinjiang Military Command,Urumqi 830099,China)

机构地区：[1]新疆医科大学研究生院,乌鲁木齐830054 [2]新疆军区总医院输血科,乌鲁木齐830099

出　　处：《协和医学杂志》2025年第1期75-82,共8页Medical Journal of Peking Union Medical College Hospital

摘　　要：膝骨关节炎(knee osteoarthritis,KOA)是一种常见的膝关节退行性疾病,病理特征为滑膜炎症、软骨丢失等,常表现为关节疼痛和活动功能受限,严重影响患者的生活质量。传统治疗手段,如药物注射和手术干预,主要致力于缓解症状,对于软骨的修复效果有限。人脐带间充质干细胞(human umbilical cord mesenchymal stem cells,hUC-MSCs)因具有抗炎和软骨再生能力,成为治疗KOA的新希望。本文结合国内外最新研究成果,对临床中应用hUC-MSCs治疗KOA的理论依据、研究设计及疗效评价进行论述,同时围绕hUC-MSCs临床应用中面临的问题,以及未来需攻克的方向展开探讨,以期为临床应用hUC-MSCs治疗KOA提供理论支持。Knee osteoarthritis(KOA)is a prevalent degenerative joint disease characterized by synovial inflammation,cartilage loss.Often manifesting as joint pain and limited mobility,it severely affects the quality of life of patients.Traditional treatment methods such as pharmacological injections and surgical interventions primarily aim to alleviate symptoms but have limited effects on cartilage repair.Human umbilical cord mesenchymal stem cells(hUC-MSCs),due to their anti-inflammatory and chondrogenic capabilities,is considered a new hope for the treatment of KOA.This article synthesizes the latest research findings from both domestic and international sources to discuss the theoretical basis for the clinical application of hUC-MSCs in treating KOA,clinical study design,and efficacy evaluation.It also addresses the challenges in the clinical application of hUC-MSCs and explores future directions,in the hope of providing feasible theoretical support for the treatment of KOA with hUC-MSCs.

关 键 词：人脐带间充质干细胞 膝骨关节炎 软骨再生 

分 类 号：R593[医药卫生—内科学] R592[医药卫生—临床医学]