微生态菌群与子宫内膜异位症相关性研究进展  

Research Progress on the Correlation Between Microecological Flora and Endometriosis

作　　者：李茂萍 常珩 LI Maoping;CHANG Heng(Graduate School of Xinjiang Medical University,Urumqi 830000,China;Department of Obstetrics and Gynecology,General Hospital of Xinjiang Military Command,Urumqi 830000,China)

机构地区：[1]新疆医科大学研究生院,乌鲁木齐830000 [2]新疆军区总医院妇产科,乌鲁木齐830000

出　　处：《协和医学杂志》2025年第1期184-191,共8页Medical Journal of Peking Union Medical College Hospital

摘　　要：微生态菌群是人体微环境的重要组成部分,可随人体内外环境的改变而发生变化,对维系人体正常功能具有重要作用。子宫内膜异位症(endometriosis, EMs)是一种雌激素依赖性女性常见病,表现为子宫内膜腺体和间质在子宫腔以外的部位种植生长。现有研究表明,肠道、生殖道菌群失衡可引发局部免疫炎症反应,并通过细胞因子和代谢通路引起全身免疫炎症反应,进而参与EMs进展。通过微生态菌群干预对EMs进行诊断与治疗是该领域的研究热点之一。本文将对微生态菌群失衡与EMs相关性研究进展作一综述,以期为EMs的诊疗提供更多借鉴。Microecological flora,an important part of the human microenvironment,changes with the changes in the internal and external environments of the human body,and plays an important role in maintaining human body's normal function.Endometriosis(EMs)is a common estrogen-dependent female disease chara-cterized by the growth of endometrial glands and mesenchyme outside the uterine cavity.Existing studies have shown that imbalance of intestinal and reproductive tract flora can trigger local immune-inflammatory responses and cause systemic immune-inflammatory responses through cytokines and metabolic pathways,which in turn participate in the progression of EMs.Thus,the diagnosis and treatment of EMs through microecological flora interventions is one of the hotspots research in this field.This article aims to review the research progress on the correlation between microbial dysbiosis and EMs,with the hope of providing more references for the treatment of EMs.

关 键 词：子宫内膜异位症 微生态失衡 生殖道微生态 肠道微生态 肠脑轴 

分 类 号：R711.71[医药卫生—妇产科学] R-1[医药卫生—临床医学]