以抗阻运动为主的运动处方对超重和肥胖成年人群糖脂代谢影响的Meta分析  

Meta-Analysis of the Effect of Resistance Exercise Prescription on Glucose and Lipid Metabolism in Overweight and Obese Adults

作　　者：孙宇欣 郭晓湲 陈适[1] 潘慧[1,2] 朱惠娟 SUN Yuxin;GUO Xiaoyuan;CHEN Shi;PAN Hui;ZHU Huijuan(Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China;State Key Laboratory of Complex,Severe and Rare Diseases,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院内分泌科,北京100730 [2]中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室,北京100730

出　　处：《协和医学杂志》2025年第1期235-247,共13页Medical Journal of Peking Union Medical College Hospital

基　　金：中央引导地方科技发展资金项目(XZ202101YD0002C);国家重点研发计划“主动健康和人口老龄化科技应对”重点专项(2022YFC3600203)。

摘　　要：目的探讨抗阻运动对超重或肥胖成年人群糖脂代谢的效果,以期为临床制订合适的抗阻运动方案提供依据。方法系统检索PubMed、Cochrane Library、EmBase、Web of Science、中国知网、万方数据知识服务平台、维普中文科技期刊全文数据库从建库至2023年12月31日抗阻运动对超重和肥胖人群糖脂代谢影响的相关文献。文献类型限定为随机对照试验,其中试验组的运动干预包含抗阻运动,对照组不包含抗阻运动。由2名研究人员按照纳入与排除标准对文献进行筛选,并提取相关数据。采用RevMan 5.3软件对纳入文献进行Meta分析,采用漏斗图评估文献发表偏倚情况。结果共纳入17篇文献,700例研究对象,其中试验组351例,对照组349例。Meta分析结果显示,与对照组比较,试验组糖化血红蛋白[SMD(95%CI)=-0.30(-0.53~-0.07),P=0.010]、空腹血糖[SMD(95%CI)=-0.58(-0.90~-0.26),P<0.001]、胰岛素抵抗指数[SMD(95%CI)=-0.90(-1.42~-0.38),P<0.001]、低密度脂蛋白胆固醇[SMD(95%CI)=-0.28(-0.53~-0.04),P=0.020]水平降低。亚组分析显示,采用单纯抗阻运动和抗阻-有氧运动混合运动模式的试验组糖代谢水平均低于对照组(P均<0.05);抗阻运动对亚洲人群(I^(2)=57%)的糖代谢影响异质性较高加索(I^(2)=76%)和其他人群(I^(2)=94%)小,且糖代谢指标下降水平显著[SMD(95%CI)=-1.15(-1.73~-0.57),P<0.001]。结论抗阻运动可显著降低超重或肥胖成年人群的糖脂代谢水平。Objective To explore the effect of resistance exercise on glycolipid metabolism in over-weight or obese people,with the aim of providing reference for the clinical development of appropriate resistance exercise programs.Methods PubMed,Cochrane Library,EmBase,Web of Science,CNKI,Wanfang Data Knowledge Service Platform and VIP database were systematically searched to obtain the relevant literature on the effects of resistance exercise on glucose and lipid metabolism from the establishment of the library to December 31,2023 in overweight and obese populations.The type of literature was limited to randomized controlled studies in which the exercise intervention included resistance exercise in the test group but did not include resistance exercise in the control group.The literature was screened by 2 researchers according to inclusion and exclusion criteria and relevant data were extracted.Meta-analysis of included literature was performed using RevMan 5.3 software,and publication bias was assessed using funnel plots.Results A total of 17 papers and 700 study subjects were included,with 351 cases in the test group,and 349 cases in the control group.Meta-analysis results showed that compared with the control group,the glycosylated hemoglobin of the test group with resistance exercise[SMD(95%CI)=-0.30(-0.53--0.07),P=0.010],fasting blood glucose[SMD(95%CI)=-0.58(-0.90--0.26),P<0.001],insulin resistance index[SMD(95%CI)=-0.90(-1.42--0.38),P<0.001],and low-density lipoprotein cholesterol(LDL-C)[SMD(95%CI)=-0.28(-0.53--0.04),P=0.020]levels were reduced.Subgroup analysis showed that the glucose metabolism levels of the test group with only resistance exercise and a combination of resistance-anaerobic exercise were significantly lower than those of the control group(both P<0.05).The heterogeneity of the effect of resistance exercise on glucose metabolism in Asian populations(I^(2)=57%)was smaller than that in Caucasion(I^(2)=76%)and other populations(I^(2)=94%),and the level of decrease in glucose metabolism indexes was signi

关 键 词：抗阻运动 超重 肥胖 糖脂代谢 META分析 

分 类 号：R446[医药卫生—诊断学] R589[医药卫生—临床医学] R589.2