羊水干细胞分化机制研究进展  

Research progress on the differentiation mechanism of amniotic fluid stem cells

作　　者：娄焕英 季莹莹 张帅[1] 查斌斌 孙晶 王凤[1] 李毅[1] LOU Huanying;JI Yingying;ZHANG Shuai;CHA Binbin;SUN Jing;WANG Feng;LI Yi(Laboratory of Prenatal Diagnosis,the Affiliated Tai’an Central Hospital of Qingdao University,Tai’an 271000,China)

机构地区：[1]青岛大学附属泰安市中心医院产前诊断实验室,山东泰安271000

出　　处：《陕西医学杂志》2025年第2期277-281,共5页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(31200983);山东省医药卫生科技发展计划项目(2017WS598);山东省泰安市科技创新发展项目(2021NS337);泰安市中心医院苗圃培育项目(2021MPM04)。

摘　　要：羊水干细胞(AFSCs)作为一类新型多能干细胞,因其易于获取、低免疫原性及多向分化潜能等特性,近年来在再生医学、组织工程、疾病模型构建及药物筛选等多个领域展现出巨大潜力。羊水干细胞的分化受到多种因素的调控,但其分化机制的研究进展有待阐明和总结。现对AFSCs分化过程中的信号通路、表观遗传修饰等关键调控因素、微环境影响以及AFSCs在医学领域中的应用进行了综述。Amniotic fluid stem cells(AFSCs),as a new type of pluripotent stem cells,have shown great potential in various fields such as regenerative medicine,tissue engineering,disease modeling,and drug screening in recent years due to their unique characteristics,including ease of access,low immunogenicity and multi-directional differentiation potential.The differentiation of AFSCs is regulated by multiple factors,but the research progress on their differentiation mechanisms remains to be clarified and summarized.This article reviews the key regulatory factors such as signaling pathways,epigenetic modifications and micro-environmental influences during the differentiation process and the applications of AFSCs in the medical field.

关 键 词：羊水干细胞 分化机制 信号通路 表观遗传修饰 微环境 

分 类 号：R392.2[医药卫生—免疫学]