One Novel Nortriterpenoid from the Mastic(Pistacia lentiscus)and Its Anti-Inflammatory Activity  

作　　者：Yan Wu Xuerui An Haofan Lv Zhiqiang Zhao Wei Liu Chunpeng Wan 

机构地区：[1]Key Lab of Natural Product Chemistry and Application at Universities of Education Department of Xinjiang Uygur Autonomous Region,School of Chemistry and Chemical Engineering,Yili Normal University,Yining,835000,China [2]Xinjiang Key Laboratory of Clean Conversion and High Value Utilization of Biomass Resources,School of Chemistry and Chemical Engineering,Yili Normal University,Yining,835000,China [3]Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits and Vegetables,College of Agronomy,Jiangxi Agricultural University,Nanchang,330045,China

出　　处：《Phyton-International Journal of Experimental Botany》2025年第1期199-207,共9页国际实验植物学杂志(英文)

基　　金：National Natural Science Foundation of China(Grant No.82060774);Key Special Projects for Enhancing Subject Comprehensive Strength at Yili Normal University(Project No.22XKZZ08);Open Project of Jiangxi Provinicial Key Laboratory of Natural and Biomimetic Drugs Research(Project No.2024SSY07051).

摘　　要：A novel pair of oleanane nor-triterpenes,with compound 1 featuring a unique 18α-H structure,was isolated from mastic,and this compound represents a noteworthy new entity not previously reported in the literature.The absolute configurations of their structures were further determined using a combination of different analytical methods such as NMR,high-resolution mass spectrometry(HR-MS),ultraviolet(UV),infrared(IR)and single-crystal X-ray diffraction(SXRD).The compound actively mitigated inflammations by efficiently quenching nitric oxide(NO)synthesis within an ex vivo system using lipopolysaccharide activated murine macrophage RAW264.7 cells.Moreover,compound 1 exhibit a better IC_(50) concentration of 11.69±1.39µM,surpassing the efficacy of the positive control dexamethasone,which exhibited an IC50 of 23.21±1.17μM.While compound 2 also demonstrated inhibitory activity,its potency was comparatively weaker,with an IC_(50) of 26.18±2.66μM.

关 键 词：MASTIC nor-triterpene 18α-H oleanane ANTI-INFLAMMATORY 

分 类 号：O62[理学—有机化学]