布地格福气雾剂联合K5压力阈值吸气肌训练仪对慢性阻塞性肺疾病急性加重期患者生命质量及呼吸功能的影响  

Effect of budesonide,glycopyrronium bromide and for‐moterol fumarate inhalation aerosol combined with K5 pressure threshold inspiratory muscle training device on the quality of life and respiratory function in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：黄玉梅 龚享文 李志腾 卢沂沂 陈优梅 HUANG Yumei;GONG Xiangwen;LI Zhiteng;LU Yiyi;CHEN Youmei(Department of Respiratory and Critical Care Medicine,The Fifth People's Hospital of Ganzhou,Ganzhou,Jiangxi,341000,China)

机构地区：[1]赣州市第五人民医院呼吸与危重症医学科,江西赣州341000

出　　处：《当代医学》2024年第23期43-47,共5页Contemporary Medicine

摘　　要：目的探讨布地格福气雾剂联合K5压力阈值吸气肌训练仪对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary diseas,AECOPD)患者生命质量及呼吸功能的影响。方法选取2021年1—12月赣州市第五人民医院收治的80例AECOPD患者作为研究对象,按照随机数字表法分为对照组与治疗组,每组40例。对照组予布地格福气雾剂治疗,治疗组在对照组基础上加用K5压力阈值吸气肌训练仪训练。比较两组治疗前后生命质量[圣乔治呼吸问卷评分量表(St.George's breath questionnaire,SGRQ)、慢性阻塞性肺疾病评估测试问卷(chronic obstructive pulmonary disease assessment test,CAT)]、6 min步行试验(6-minute walk test,6MWT)、肺功能[第1秒用力呼气容积(forced expiratory volume in the first second,FEV1)、用力肺活量(forced vital capacity,FVC)、肺一氧化碳弥散量(diffusing capacity for carbon monoxide,DLCO)、每升肺泡容积的一氧化碳弥散量(diffusion capacity for carbon monoxide per liter of alveolar volume,DLCO/VA)]、血气分析指标[动脉血氧饱和度(arterial oxygen saturation,SaO2)、动脉血氧分压(partial pressure of arterial oxygen,PO2)和动脉血二氧化碳分压(partial pressure of carbon dioxide,PCO_(2))]、呼吸肌力[最大吸气压(maximum inspiratory pressure,MIP)]及不良反应发生情况。结果治疗后,两组SGRQ、CAT评分均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组6MWT均长于治疗前,FEV1、FVC均大于治疗前,DLCO、DLCO/VA均高于治疗前,且治疗组6MWT长于对照组,FEV1、FVC均大于对照组,DLCO、DLCO/VA均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组SaO2、PO2、MIP均高于治疗前,PCO_(2)低于治疗前,且治疗组SaO2、PO2、MIP均高于对照组,PCO_(2)低于对照组,差异有统计学意义(P<0.05)。两组治疗期间血尿常规、肝肾功能未见异常,两组不良反应发生率比较差异无统计学意�Objective To investigate the effect of budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol combined with K5 pressure threshold inspiratory muscle training device on the quality of life and respiratory function in patients with acute exacerbation of chronic obstructive pulmonary diseas(AECOPD).Methods 80 patients with AECOPD who were admitted to The Fifth People's Hospital of Ganzhou from January to December 2021 were selected as the research subjects,they were divided into the control group and the treatment group acorrding to the random number table method,with 40 cases in each group.The control group was treated with budesonide,glycopyrronium bromide and formoterol fumarate inhalation aerosol,the treatment group received training using K5 pressure threshold inspiratory muscle training device on the basis of the control group.The quality of life(St.George's breath questionnaire[SGRQ]and chronic obstructive pulmonary disease assessment test[CAT]),6-min walk test(6MWT),pulmonary function(forced expiratory volume in the first second[FEV1],forced vital capacity[FVC],diffusing capacity for carbon monoxide[DLCO]and diffusion capacity for carbon monoxide per liter of alveolar volume[DLCO/VA]),blood gas analysis indexes(arterial oxygen saturation[SaO2],partial pressure of arterial oxygen[PO2]and partial pressure of carbon dioxide in arterial blood[PCO2],respiratory(muscle strength maximum inspiratory pressure[MIP])before and after treatment and the incidence of adverse reactions were compared between the two groups.Results After treatment,SGRQ and CAT scores of the two groups were lower than those before treatment,and the treatment group was lower than the control group,the differences were statistically significant(P<0.05).After treatment,the 6MWT was longer than that before treatment,FEV1 and FVC were greater than those before treatment,DLCO and DLCO/VA were larger than those before treatment,and the 6MWT in the treatment group was longer than that in the control group,FEV1 and FVC were greate

关 键 词：慢性阻塞性肺疾病急性加重期 布地格福 压力阈值吸气肌训练 生命质量 呼吸功能 

分 类 号：R56[医药卫生—呼吸系统]