利托君联合硫酸镁对未足月早产胎膜早破患者血清炎症因子水平及不良反应的影响  

Effect of ritodrine combined with magnesium sulfate on serum inflammatory factor levels and adverse reactions in patients with premature rupture of membranes in preterm unterm labor

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作  者:薛小红 稂小敏 刘燕红 张小芳[3] 杨小燕 XUE Xiaohong;LANG Xiaomin;LIU Yanhong;ZHANG Xiaofang;YANG Xiaoyan(Department of Obstetrics and Gynecology,Ji'an Maternal and Child Health Hospital,Ji'an,Jiangxi,343000,China;Department of Women's Rehabilitation,Ji'an Maternal and Child Health Hospital,Ji'an,Jiangxi,343000,China)

机构地区:[1]吉安市妇幼保健院产科,江西吉安343000 [2]吉安市妇幼保健院妇女康复科,江西吉安343000 [3]吉安市妇幼保健院妇产科,江西吉安343000

出  处:《当代医学》2024年第23期75-79,共5页Contemporary Medicine

摘  要:目的探究利托君联合硫酸镁对未足月早产胎膜早破患者血清炎症因子水平及不良反应的影响。方法选取2019年1月至2021年12月吉安市妇幼保健院接收的80例未足月早产胎膜早破患者作为研究对象,按照随机数字表法分为观察组与对照组,每组40例。对照组给予硫酸镁治疗,观察组给予利托君联合硫酸镁治疗。比较两组血清炎症因子[白细胞介素-6(interleukin-6,IL-6)、降钙素原(procalcitonin,PCT)、超敏C-反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞介素-2(interleukin-2,IL-2)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及γ干扰素(interferon-γ,IFN-γ)]水平、胎儿情况[纤维连接蛋白(fibronectin,fFN)、线粒体膜电位(mitochondrial membrane potential,MMP)与胰岛素样生长因子结合蛋白-1(insulin-like growth factor binding protein-1,IGFBP-1)]、妊娠结局、临床疗效及不良反应发生情况。结果治疗后,观察组IL-6、PCT、hs-CRP、IL-2、TNF-α及IFN-γ水平均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组胎儿fFN、MMP、IGFBP-1水平均低于对照组,差异有统计学意义(P<0.05)。观察组孕龄延长时间、宫缩抑制时间均长于对照组,产后出血量少于对照组,新生儿体质量大于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为95.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。观察组不良反应发生率为12.50%,低于对照的40.00%,差异有统计学意义(P<0.05)。结论利托君联合硫酸镁治疗未足月早产胎膜早破患者疗效确切,可改善患者血清炎症因子水平及妊娠结局,降低不良反应发生率,值得临床推广应用。Objective To explore the effect of ritodrine combined with magnesium sulfate on serum inflammatory factor levels and adverse reactions in patients with premature rupture of membranes in preterm unterm labor.Methods 80 cases of premature rupture of membranes in incomplete preterm labor admitted to Ji'an Maternal and Child Health Hospital from January 2019 to December 2021 were selected as the study subjects,they were divided into the observation group and the control group according to the random number table method,with 40 cases in each group.The control group was treated with magnesium sulfate,and the observation group was treated with ritodrine supplemented combined with magnesium sulfate.The levels of serum inflammatory factors(interleukin-6[IL-6],procalcitonin[PCT],high-sensitivity C-reactive protein[hs-CRP],interleukin-2[IL-2],tumor necrosis factor-α[TNF-α]and interferon-γ[IFN-γ]),fetal condition(fibronectin[fFN],mitochondrial membrane potential[MMP]and insulin-like growth factor binding protein-1[IGFBP-1]),pregnancy outcomes,clinical efficacy and incidence of adverse reactions were compared between the two groups.Results After treatment,the levels of IL-6,PCT,hsCRP,IL-2,TNF-αand IFN-γin the observation group were lower than those in the control group,and the differences were statistically signifincant(P<0.05).After treatment,the fetal of fFN,MMP and IGFBP-1 levels in the observation group were lower than those in the control group,and the differences were statistically signifincant(P<0.05).The gestational age extension and contraction inhibition time were longer than those in the control group,the postpartum hemorrhage was shorter than that in the control group,the newborn's weight was higher than that in the control group,and the differences were statistically signifincant(P<0.05).The effective rate of treatment in the observation group was 95.00%,which was higher than 80.00%in the control group,and the difference was statistically signifincant(P<0.05).The incidence of adverse reactions in the observ

关 键 词:利托君 硫酸镁 未足月早产胎膜早破 炎症因子 

分 类 号:R71[医药卫生—妇产科学]

 

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