拮抗剂与微刺激促排卵方案治疗高龄不孕女性的效果比较  

Comparison of the efficacy of antagonist and micro stimulation for ovulation induction in the treatment of elderly infertile women

作　　者：金艳梅 杨岚[1] 罗琼秀[1] JIN Yanmei;YANG Lan;LUO Qiongxiu(Department of Reproductive,Ji'an Maternal and Child Health Hospital,Ji'an,Jiangxi,343000,China)

机构地区：[1]吉安市妇幼保健院生殖科,江西吉安343000

出　　处：《当代医学》2024年第23期150-153,共4页Contemporary Medicine

基　　金：吉安市科技计划项目〔吉市科计字[2019]8号(91)〕。

摘　　要：目的比较拮抗剂与微刺激促排卵方案治疗高龄不孕女性的临床效果。方法选取2019年5月至2022年5月吉安市妇幼保健院收治的80例高龄不孕患者作为研究对象,按照随机数字表法分为拮抗剂组与微刺激组,每组40例。拮抗剂组采用拮抗剂促排卵方案治疗,微刺激组采用微刺激促排卵方案治疗,比较两组促排卵效果与妊娠结局。结果两组获卵数与优质胚胎数比较差异无统计学意义;拮抗剂组促性腺激素(gonadotropin,Gn)使用时间长于微刺激组,Gn用量多于微刺激组,差异有统计学意义(P<0.05)。两组妊娠率、异位妊娠率与流产率比较差异无统计学意义;拮抗剂组周期取消率低于微刺激组,差异有统计学意义(P<0.05)。结论拮抗剂促排卵方案可明显降低患者周期取消率,微刺激促排卵方案可改善Gn使用情况,临床需根据患者的实际需求,选用合适的促排卵方案。Objective To compare the clinical efficacy of antagonist and micro-stimulation for ovulation induction in the treatment of elderly infertile women.Methods 80 elderly infertile patients admitted to Ji'an Maternal and Child Health Hospital from May 2019 to May 2022 were selected as the research subjects,and they were divided into the antagonist group and the micro-stimulation group according to the random number table method,with 40 cases in each group.The antagonist group was treated with antagonist ovulation induction scheme,while the micro-stimulation group was treated with micro-stimulation ovulation induction scheme,the clinical efficacy and pregnancy outcome were compared between the two groups.Results There was no significant difference in the number of eggs obtained and the number of high-quality embryos between the two groups;the usage time of gonadotropin(Gn)in the antagonist group was longer than that in the micro-stimulation group,and the dosage of Gn in the antagonist group was more than that in the micro-stimulation group,and the differences were statistically significant(P<0.05).There were no significant differences in pregnancy rate,ectopic pregnancy rate and abortion rate between the two groups;the cycle cancellation rate in the antagonist group was lower than that in the micro-stimulation group,and the difference was statistically significant(P<0.05).Conclusion The antagonist ovulation promotion scheme can significantly reduce the cycle cancellation rate of patients,and the micro-stimulation ovulation promotion scheme can improve the use of Gn,the clinical need to select the appropriate ovulation promotion scheme according to the actual needs of patients.

关 键 词：高龄不孕 拮抗剂 微刺激 促排卵方案 

分 类 号：R71[医药卫生—妇产科学]