盐酸氨溴索联合莫西沙星治疗老年慢性支气管炎急性发作的临床效果  

Clinical Effect of Ambroxol Hydrochloride Combined with Moxifloxacin in Treatment of Acute Exacerbation of Chronic Bronchitis in Elderly

作　　者：沈慧芳 Shen Huifang(Emergency Medicine Department,The Fourth Affiliated Hospital of Nanjing Medical University,Nanjing 210031,Jiangsu Province,China)

机构地区：[1]南京医科大学第四附属医院急诊医学科,江苏南京210031

出　　处：《中国社区医师》2025年第1期42-44,共3页Chinese Community Doctors

摘　　要：目的:观察盐酸氨溴索联合莫西沙星治疗老年慢性支气管炎急性发作(AECB)的临床效果。方法:选取2023年9月—2024年11月南京医科大学第四附属医院收治的68例老年AECB患者作为研究对象,根据双色球法分为常规组与试验组,各34例。常规组给予莫西沙星治疗,试验组采用盐酸氨溴索联合莫西沙星治疗。比较两组治疗效果。结果:试验组症状控制时间均短于常规组(P<0.05)。治疗后,两组第1秒用力呼气容积、用力肺活量、第1秒用力呼气容积/用力肺活量均提高,且试验组高于常规组(P<0.05)。治疗后,两组肿瘤坏死因子-α、C反应蛋白和白细胞介素-8水平均降低,且试验组降幅大于常规组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P=0.690)。结论:盐酸氨溴索联合莫西沙星治疗老年AECB的效果确切,利于控制患者症状,改善肺功能,减轻炎症,且用药安全性高。Objective:To observe the clinical effect of ambroxol hydrochloride combined with moxifloxacin in treatment of acute exacerbation of chronic bronchitis(AECB)in elderly.Methods:A total of 68 elderly patients with AECB admitted to the Fourth Affiliated Hospital of Nanjing Medical University from September 2023 to November 2024 were selected as the study subjects.They were divided into a conventional group and an experimental group,with 34 cases in each group,according to the double-color ball method.The conventional group was treated with moxifloxacin and the experimental group was treated with ambroxol hydrochloride combined with moxifloxacin.The treatment effects were compared between the two groups.Results:The symptom control time in the experimental group was shorter than that in the conventional group(P<0.05).After treatment,the forced expiratory volume in 1 second,forced vital capacity,and forced expiratory volume in 1 second/forced vital capacity in two groups increased,and these indexes in the experimental group were higher than those in the conventional group(P<0.05).After treatment,the levels of tumor necrosis factor-α,C-reactive protein and interleukin-8 in the two groups decreased,and the decrease in the experimental group was greater than that in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P=0.690).Conclusion:The ambroxol hydrochloride combined with moxifloxacin has definite effects in the treatment of elderly AECB,and can control the symptoms of patients,improve lung function,and relieve inflammatory reactions,with high medication safety.

关 键 词：莫西沙星 盐酸氨溴索 老年 慢性支气管炎 急性发作 

分 类 号：R562.2[医药卫生—呼吸系统]