特发性膜性肾病患者血清β_(2)微球蛋白与肾脏病理的相关性研究  

Correlation between serumβ_(2)-microglobulin and renal pathology in patients with idiopathic membranous nephropathy

作　　者：曾秀琴[1] 李荣忠 曾庆义[1] 周才芳 陈灿 ZENG Xiuqin;LI Rongzhong;ZENG Qingyi;ZHOU Caifang;CHEN Can(Department of Nephrology,the Third People's Hospital of Huizhou,Guangdong Province,Huizhou 516000,China)

机构地区：[1]广东省惠州市第三人民医院肾内科,广东惠州516000

出　　处：《中国当代医药》2024年第35期23-27,共5页China Modern Medicine

基　　金：广东省惠州市医疗卫生领域科技计划项目(2023CZ010168)。

摘　　要：目的探讨特发性膜性肾病(IMN)患者血清β_(2)微球蛋白(β_(2)-MG)与肾脏病理的相关性。方法回顾性分析2012年12月至2023年5月惠州市第三人民医院肾内科收治的156例IMN患者的临床资料,并将其纳入IMN组,另选取同期在惠州市第三人民医院接受健康体检的156名健康受检者纳入健康组。比较两组的血清β_(2)-MG水平与相关临床指标;比较不同病理分期、不同病理积分亚组IMN患者的血清β_(2)-MG水平,分析血清β_(2)-MG与病理指标、临床指标的相关性。结果血清β_(2)-MG≥1.500 mg/L对IMN具有中等诊断价值(AUC=0.803,P<0.05);血清β_(2)-MG≥1.540 mg/L对IMN病理分期具有较低评估价值(AUC=0.659,P<0.05);血清β_(2)-MG≥1.895 mg/L对IMN病理积分具有较高评估价值(AUC=0.981,P<0.05)。血清β_(2)-MG与IMN病理分期具有低度正相关性(r=0.424,P<0.05),与IMN病理积分具有高度正相关性(r=0.910,P<0.05)。结论IMN患者的血清β_(2)-MG水平与病理分期、病理积分间具有正相关性,可为IMN的诊断与临床病理分析提供必要参考。Objective To investigate the correlation between serumβ_(2)-microglobulin(β_(2)-MG)and renal pathology in patients with idiopathic membranous nephropathy(IMN).Methods The clinical data of 156 patients with IMN admitted to the Department of Nephrology,the Third People's Hospital of Huizhou from December 2012 to May 2023 were retrospectively analyzed,and they were included in the IMN group.In addition,156 healthy subjects who underwent physical examination in the Third People's Hospital of Huizhou during the same period were selected as the healthy group.The serumβ_(2)-MG levels and related clinical indicators were compared between the two groups.The levels of serumβ_(2)-MG in IMN patients with different pathological stages and different pathological score subgroups were compared,and the correlation between serumβ_(2)-MG and pathological and clinical indicators was analyzed.Results Serumβ_(2)-MG≥1.500 mg/L had moderate diagnostic value for IMN(AUC=0.803,P<0.05).Serumβ_(2)-MG≥1.540 mg/L had a low evaluation value for pathological stage of IMN(AUC=0.659,P<0.05).Serumβ_(2)-MG≥1.895 mg/L had a high evaluation value for IMN pathological score(AUC=0.981,P<0.05).Serumβ_(2)-MG level had a low positive correlation with IMN pathological stage(r=0.424,P<0.05)and a high positive correlation with IMN pathological score(r=0.910,P<0.05).Conclusion The level of serumβ_(2)-MG in IMN patients is positively correlated with pathological stage and pathological score,which can provide necessary reference for the diagnosis and clinicopathological analysis of IMN.

关 键 词：特发性膜性肾病 血清β_(2)微球蛋白 病理 相关性 

分 类 号：R692[医药卫生—泌尿科学]