剪切波弹性成像评价大鼠急性肝淤血状态下肝脏黏弹性变化  

Evaluation of liver viscoelastic changes in rats with acute liver congestion by shear wave elastography

作　　者：王雨萌 王昆 蔺雨萱 刘冬[1] WANG Yumeng;WANG Kun;LIN Yuxuan;LIU Dong(Department of Ultrasound Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院超声医学科,北京100050

出　　处：《临床超声医学杂志》2025年第1期1-5,共5页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金项目(82001819)。

摘　　要：目的建立大鼠急性肝淤血模型,应用剪切波弹性成像评价其急性肝淤血状态下肝脏黏弹性的变化情况。方法选取雄性SD大鼠14只,通过结扎大鼠下腔静脉建立急性肝淤血模型。于活体状态下应用剪切波弹性成像测量结扎前、结扎后及结扎释放后大鼠肝脏黏性值和弹性值,比较上述参数的差异。分析肝脏黏性值与弹性值的相关性;比较急性肝淤血状态下肝脏黏性值与弹性值变化率和达峰时间。结果结扎后大鼠肝脏黏性值和弹性值均较结扎前升高,结扎释放后大鼠肝脏黏性值和弹性值均较结扎后降低,差异均有统计学意义(均P<0.001);结扎前与结扎释放后大鼠肝脏黏性值和弹性值比较差异均无统计学意义。相关性分析显示,肝脏黏性值与弹性值呈正相关(r=0.902,P<0.001)。急性肝淤血状态下大鼠肝脏弹性值上升及下降变化率均显著高于黏性值上升及下降变化率,差异均有统计学意义(t=5.63、5.49,均P<0.001)。结扎后大鼠肝脏弹性值达峰时间为122 s(95%可信区间:106~138 s),黏性值达峰时间为110 s(95%可信区间:92~128 s),二者比较差异无统计学意义。结论应用剪切波弹性成像可以评价大鼠急性肝淤血状态下肝脏黏弹性的变化情况;急性肝淤血状态下其肝脏黏弹性参数均升高,解除肝淤血后其肝脏黏弹性参数均可恢复至正常水平。Objective To establish acute liver congestion models in rats,and to evaluate the liver viscoelastic changes by shear wave elastography.Methods Fourteen male SD rats were selected to establish acute congestion liver models by ligation of inferior vena cava.Shear wave elastography was applied to measure liver viscosity and elasticity of rats in vivo before ligation,after ligation,and after ligation release.The differences of the above parameters were compared.The correlation between liver viscosity and elasticity was analyzed.Additionally,the change rate in liver viscosity and elasticity and peak time under acute liver congestion were compared.Results After ligation,the viscosity and elasticity of rats livers significantly increased compared with those before ligation(both P<0.001).After ligation release,the viscosity and elasticity of rats livers significantly decreased compared with those before after ligation(both P<0.001).There were no significant difference in viscosity and elasticity of rats livers before and after ligation.Correlation analysis showed that viscosity was positive correlated with elasticity(r=0.902,P<0.001).In the acute liver congestion state,the change rate of increasing and decreasing of liver elasticity in rats were significantly higher than those of viscosity(t=5.63,5.49,both P<0.001).After ligation,the peak time of rat livers elasticity was 122 s(95%confidence interval:106~138 s),and the peak time of rat livers viscosity was 110 s(95%confidence interval:92~128 s),there was no significant difference between the two items.Conclusion Shear wave elastography can be used to evaluate the changes in liver viscoelasticity in rats with acute liver congestion.In the acute liver congestion state,both liver viscosity and elasticity parameters are increased,and the viscoelastic parameters can return to normal level after ligation release.

关 键 词：剪切波弹性成像 肝脏 黏弹性 急性肝淤血 大鼠 

分 类 号：R445.1[医药卫生—影像医学与核医学]