声压电动力学治疗的研究进展  

Research progress of sono-piezo dynamic therapy

作　　者：王妍[1] 王娴[2] 钱晓芹 WANG Yan;WANG Xian;QIAN Xiaoqin(Jiangsu University,Zhenjiang 212013,China;Department of Ultrasound Medicine,Jiangsu University Affiliated People’s Hospital,Zhenjiang 212002,China;Department of Ultrasound Medicine,Northern Jiangsu People’s Hospital,the Yangzhou Clinical Medical College of Jiangsu University,Yangzhou 225001,China)

机构地区：[1]江苏大学,江苏镇江212013 [2]江苏大学附属人民医院超声医学科,江苏镇江212002 [3]苏北人民医院,江苏大学扬州临床医学院超声医学科,江苏扬州225001

出　　处：《临床超声医学杂志》2025年第1期82-86,共5页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金面上项目(82471987);2023年度镇江市科技创新资金(SH2023049)。

摘　　要：声动力学治疗作为一种新型的无创治疗方法,利用低强度超声激活声敏剂产生活性氧,从而诱导细胞氧化损伤和死亡,在组织穿透力及减少副作用方面具有显著优势。然而,目前高效的声敏剂仍非常匮乏。近年来,以压电材料作为新型的声敏剂逐渐引起关注,其具有独特的压电效应,在超声作用下可促进电荷载流子的分离和迁移,催化氧化还原反应,从而有效地增加活性氧产生,实现了超声-机械能-化学能的转化,被称为声压电动力学治疗(SPDT)。目前SPDT已被证实在癌症治疗、细菌耐药、动脉粥样硬化、神经修复等方面均具有广阔的应用前景,本文就SPDT的作用机制及其在疾病治疗中的研究进展进行综述。As a novel non-invasive treatment modality,sonodynamic therapy(SDT)utilizes low-intensity ultrasound(US)to trigger sonosensitizers to generate reactive oxygen species(ROS),which induce cellular oxidative damage and death,and has remarkable advantages in tissue penetration and reduced side effects.However,efficient sonosensitizers are still scarce.Recently,piezoelectric semiconductor nanomaterials have garnered attention as new types of sonosensitizers.These piezoelectric nanomaterials leverage their unique piezoelectric effect to enhance the separation and migration of electron/hole pair under ultrasound stimulation,thereby catalyzing the redox reactions of substrates and effectively increasing ROS production.This process realizes the conversion of ultrasound-mechanical energy into chemical energy,a phenomenon known as sono-piezo dynamic therapy(SPDT).SPDT holds promising applications across various biomedical fields,including cancer treatment,bacterial resistance,atherosclerosis,and neuron repair.This article reviews the mechanism of action of SPDT and its research progress in the treatment of diseases.

关 键 词：声动力治疗 活性氧 声敏剂 纳米材料 压电效应 

分 类 号：R445.1[医药卫生—影像医学与核医学]