线粒体相关内质网膜介导的钙稳态在卵母细胞成熟中的作用研究进展  

Research progress on the role of mitochondrial-associated endoplasmic reticulum membrane mediated calcium homeostasis in oocyte maturation

作　　者：褚梦圆 张晗[1] 许凯凯 杨嘉琪 韩云妃 周千一 闫颖[1] CHU Mengyuan;ZHANG Han;XU Kaikai;YANG Jiaqi;HAN Yunfei;ZHOU Qianyi;YAN Ying(First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin300381,China)

机构地区：[1]天津中医药大学第一附属医院、国家中医针灸临床医学研究中心,天津300381

出　　处：《中国医药导报》2025年第1期49-53,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(82104912)。

摘　　要：在卵母细胞成熟过程中,Ca^(2+)在细胞质及细胞器中的稳态平衡是保证其功能与质量的关键因素。内质网是卵母细胞的“钙库”,通过耦联结构——线粒体相关内质网膜(MAM)与线粒体协调细胞内Ca^(2+)分布,三者共同维持卵母细胞内的钙稳态。卵母细胞内的MAM通过以IP3R1-GRP75-VDAC1为主的Ca^(2+)通道和相关Ca^(2+)调节蛋白传递Ca^(2+)信号。异常的Ca^(2+)信号传导直接阻碍卵母细胞成熟,干扰减数分裂和受精,导致生育能力受损。本文主要综述MAM介导的钙稳态在卵母细胞成熟中的相关研究进展。During oocyte maturation,homeostatic balance of Ca^(2+)in cytoplasm and organelles is a key factor in ensuring its function and quality.The endoplasmic reticulum is“calcium reservoir”of oocyte,which coordinates intracellular Ca^(2+)distribution through coupling structure of mitochondrial-associated endoplasmic reticulum membrane(MAM)and mitochondria,maintains calcium homeostasis in oocyte.MAM in oocytes transmits Ca^(2+)signaling through Ca^(2+)channel dominated by IP3R1-GRP75-VDAC1 and related Ca^(2+)regulatory protein.Aberrant Ca^(2+)signaling directly hinders oocyte maturation,interferes with meiosis and fertilization,and leads to impaired fertility.This article reviews related research progress on MAM-mediated calcium homeostasis in oocyte maturation.

关 键 词：线粒体相关内质网膜 CA^(2+) 卵母细胞 

分 类 号：R711[医药卫生—妇产科学]