血清CX3CL1、Omentin-1水平联合检测对冠心病急性心肌梗死患者PCI后预后不良的预测价值  

Prognostic value of combined detection of serum CX3CL1 and Omentin-1 in patients with coronary heart disease acute myocardial infarction after PCI

作　　者：霍嘉琪 田厚泽 幸世峰[1] HUO Jiaqi;TIAN Houze;XING Shifeng(Department of Cardiovascular Medicine,the Fifth Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi830011,China;Department of Spine Surgery,the Second Affiliated Hospital of Xinjiang Medical University,Xinjiang Uygur Autonomous Region,Urumqi830028,China)

机构地区：[1]新疆医科大学第五附属医院心内科,新疆乌鲁木齐830011 [2]新疆医科大学第二附属医院脊柱外科,新疆乌鲁木齐830028

出　　处：《中国医药导报》2025年第1期136-140,145,共6页China Medical Herald

基　　金：新疆维吾尔自治区科技援疆项目计划(指令性)项目(2022E02058)。

摘　　要：目的分析血清CX3CL1、Omentin-1水平联合检测对冠心病急性心肌梗死患者经皮冠状动脉介入治疗(PCI)后预后不良的预测价值。方法选取2020年2月至2023年5月新疆医科大学第五附属医院心内科收治的行PCI的850例冠心病急性心肌梗死患者作为观察对象。随访1年,按照患者预后情况分为预后良好组和预后不良组。比较两组血清CX3CL1、Omentin-1水平;分析影响患者预后不良的影响因素;受试者操作特征曲线分析CX3CL1、Omentin-1对冠心病急性心肌梗死患者PCI后预后不良的预测价值。结果预后不良组血清CX3CL1水平高于预后良好组,Omentin-1水平低于预后良好组(P<0.05)。两组年龄、心功能分级、病变支数、左室射血分数(LVEF)及甘油三酯(TG)、超敏C反应蛋白(hs-CRP)水平比较,差异有统计学意义(P<0.05)。年龄、心功能分级、TG、LVEF、hs-CRP、病变支数、CX3CL1、Omentin-1是冠心病急性心肌梗死患者PCI后预后不良的影响因素(P<0.05)。血清CX3CL1联合Omentin-1对冠心病急性心肌梗死患者PCI后预后不良的预测价值高于各指标单独检测。结论血清CX3CL、Omentin-1水平与冠心病急性心肌梗死患者PCI后不良预后相关,二者联合检测对冠心病急性心肌梗死患者PCI后预后不良的预测价值较高。Objective To analyze the prognostic value of combined detection of serum CX3CL1 and Omentin-1 in predicting poor prognosis of patients with coronary heart disease acute myocardial infarction after percutaneous coronary intervention(PCI).Methods A total of 850 patients with coronary heart disease acute myocardial infarction who underwent PCI in the Department of Cardiology,the Fifth Affiliated Hospital of Xinjiang Medical University from February 2020 to May 2023 were selected as observation objects.The patients were followed up for one year and they were divided into good prognosis group and poor prognosis group according to the prognosis.The levels of serum CX3CL1 and Omentin 1 were compared between two groups;the influencing factors affecting the poor prognosis were analyzed;the predictive value of CX3CL1 and Omentin-1 in patients with coronary heart disease acute myocardial infarction after PCI were analyzed.Results The level of serum CX3CL1 in good prognosis group was higher than that in poor prognosis group,while the level of serum Omentin-1 was lower than that in poor prognosis group(P<0.05).There were significant differences in age,cardiac function grade,number of lesions,left ventricular ejection fraction(LVEF),and the levels of triglyceride(TG),hypersensitive C-reactive protein(hs-CRP)between two groups(P<0.05).Age,cardiac function grade,TG,LVEF,hs-CRP,number of lesions,CX3CL1,and Omentin-1 were the influencing factors of poor prognosis in patients with coronary heart disease acute myocardial infarction after PCI(P<0.05).The prognostic value of serum CX3CL1 combined with Omentin-1 in patients with coronary heart disease acute myocardial infarction after PCI was higher than that of each index alone.Conclusion The levels of serum CX3CL and Omentin-1 are associated with poor prognosis in patients with coronary heart disease acute myocardial infarction after PCI,and the combined detection of CX3CL and Omentin-1 levels is of high value in predicting poor prognosis in patients with coronary heart disease acute

关 键 词：CX3CL1 OMENTIN-1 冠心病急性心肌梗死 经皮冠状动脉介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病]