倍他米松联合硫酸镁治疗未足月胎膜早破的临床效果  

Clinical effect of Betamethasone combined with Magnesium Sulfate in the treatment of preterm premature rupture of membranes

作　　者：郝玉萍 HAO Yuping(Department of Obstetrics,Heze Maternal and Child Health Care Hospital,Shandong Province,Heze 274000,China)

机构地区：[1]山东省菏泽市妇幼保健院产科,山东菏泽274000

出　　处：《中国当代医药》2025年第1期50-54,共5页China Modern Medicine

摘　　要：目的探讨倍他米松联合硫酸镁治疗未足月胎膜早破(PPROM)的临床效果。方法选取2022年10月至2024年2月菏泽市妇幼保健院收治的92例PPROM患者作为研究对象,根据随机数字表法分为对照组(46例)与研究组(46例)。对照组给予倍他米松治疗,研究组给予倍他米松联合硫酸镁治疗。比较两组的疗效指标、相关血清指标、新生儿肺功能、分娩结局及不良反应。结果研究组的持续治疗时间、宫缩抑制开始时间均短于对照组,孕龄延长时间长于对照组,产后出血量少于对照组,差异有统计学意义(P<0.05);两组患者治疗后的肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、基质金属蛋白酶-9(MMP-9)水平均低于本组治疗前,且研究组治疗后的TNF-α、IL-2、MMP-9水平均低于对照组,差异有统计学意义(P<0.05);研究组新生儿出生第1、7天的气道阻力均低于对照组,肺顺应性、功能残气量均高于对照组,差异有统计学意义(P<0.05);研究组的产妇宫内感染、新生儿出生窒息发生率低于对照组,新生儿出生体重及出生后5 min Apgar评分均高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论倍他米松联合硫酸镁应用于PPROM患者治疗中,能够缩短治疗时间,延长孕龄,减少产后出血量,降低相关血清指标水平,改善分娩结局及新生儿肺功能,且不会增加不良反应。Objective To explore the clinical effect of Betamethasone combined with Magnesium Sulfate in the treatment of preterm premature rupture of membranes(PPROM).Methods A total of 92 patients with PPROM admitted to Heze Maternal and Child Health Care Hospital from October 2022 to February 2024 were selected as the research objects.According to the random number table method,they were divided into control group(46 cases)and study group(46 cases).The control group was treated with Betamethasone,and the study group was treated with Betamethasone combined with Magnesium Sulfate.The efficacy indexes,related serum indexes,neonatal pulmonary function,delivery outcomes and adverse reactions were compared between the two groups.Results The duration of treatment and the start time of uterine contraction inhibition in the study group were shorter than those in the control group,the gestational age extension time was longer than that in the control group,and the amount of postpartum hemorrhage was less than that in the control group,and the differences were statistically significant(P<0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin-2(IL-2)and matrix metalloproteinase-9(MMP-9)in the two groups after treatment were lower than those before treatment,and the levels of TNF-α,IL-2 and MMP-9 in the study group after treatment were lower than those in the control group,and the differences were statistically significant(P<0.05).The airway resistance of neonates in the study group was lower than that in the control group on the 1st and 7th day after birth,and the lung compliance and functional residual capacity were higher than those in the control group,and the differences were statistically significant(P<0.05).The incidence rates of maternal intrauterine infection and neonatal birth asphyxia in the study group were lower than those in the control group,and the newborn birth weight and Apgar score at 5 min after birth were higher than those in the control group,and the differences were statistically significant(P<0.05).T

关 键 词：倍他米松 硫酸镁 未足月胎膜早破 临床效果 

分 类 号：R714.2[医药卫生—妇产科学]