柑橘黄酮片联合中药坐浴对混合痔术后肛周疼痛水肿及创面愈合的影响  

Effect of Citrus Flavonoids Tablets combined with traditional Chinese medicine sitz bath on perianal pain edema and wound healing after mixed hemorrhoids surgery

作　　者：樊明湖 罗来斌 邱卫明 黄荣 FAN Minghu;LUO Laibin;QIU Weiming;HUANG Rong(Department of General Surgery,Yingtan 184th Hospital,China Rongtong Medical Health Group,Jiangxi Province,Yingtan 335000,China)

机构地区：[1]中国融通医疗健康集团鹰潭一八四医院普通外科,江西鹰潭335000

出　　处：《中国当代医药》2025年第1期95-99,共5页China Modern Medicine

基　　金：江西省中医药管理局科技计划项目(2023B0013)。

摘　　要：目的探讨柑橘黄酮片联合中药坐浴对混合痔术后肛周疼痛水肿及创面愈合的影响。方法选取2022年6月至2023年9月于鹰潭市一八四医院就诊的102例混合痔术后患者作为研究对象,依据随机数字表法分为观察组和对照组,每组各51例。对照组采用中药坐浴治疗,观察组采用柑橘黄酮片联合中药坐浴治疗。比较两组患者的并发症发生情况(创口感染、创口出血、渗液),于术后1、3、7 d比较两组患者的疼痛程度[视觉模拟评分法(VAS)],于术后14 d比较两组患者的水肿程度(水肿积分量表),记录两组患者创面愈合时间并于术后7、14 d比较两组患者创面愈合率,于术后7、14 d比较两组患者的疾病相关生化指标[白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)],并比较两组患者术前及术后3个月的生活质量[生活质量综合评定问卷-74(GQOLI-74)]。结果治疗期间,观察组的并发症总发生率低于对照组,差异有统计学意义(P<0.05)。术后3、7 d,观察组患者的VAS评分均低于对照组,差异有统计学意义(P<0.05)。术后14 d,观察组的水肿积分低于对照组,差异有统计学意义(P<0.05)。观察组的创面愈合时间短于对照组,差异有统计学意义(P<0.05)。术后7、14 d,观察组的创面愈合率均高于对照组,差异有统计学意义(P<0.05)。术后7、14 d,观察组的IL-6、IL-1β水平均低于对照组,差异有统计学意义(P<0.05)。术后3个月,观察组的GQOLI-74评分高于对照组,差异有统计学意义(P<0.05)。结论中药坐浴联合柑橘黄酮片治疗可减轻混合痔患者炎症反应,加快创面愈合,缓解水肿,改善并发症发生情况。Objective To explore the effect of Citrus Flavonoids Tablets combined with traditional Chinese medicine sitz bath on perianal pain edema and wound healing after mixed hemorrhoids surgery.Methods A total of 102 patients with mixed hemorrhoids treated in Yingtan 184th Hospital from June 2022 to September 2023 were selected as the research objects.According to the random number table method,they were divided into the observation group and the control group,with 51 cases in each group.The control group was treated with traditional Chinese medicine sitz bath,while the observation group was given Citrus Flavonoids Tablets combined with traditional Chinese medicine sitz bath.The incidence of complications(wound infection,wound bleeding,exudation),the degree of pain(visual analogue scale[VAS])at 1,3 and 7 days after operation,and the degree of edema(edema integral scale)at 14 days after operation were compared between the two groups.The wound healing time of the two groups was recorded and the wound healing rates were compared between the two groups at 7 and 14 days after operation.The disease-related biochemical indexes(interleukin-6[IL-6],interleukin-1β[IL-1β])were compared between the two groups at 7 and 14 days after operation.The quality of life(general quality of life inventory-74[GQOLI-74])was compared between the two groups before and 3 months after operation.Results During the treatment,the total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The VAS scores of the observation group were lower than those of the control group at 3 and 7 days after the operation,and the differences were statistically significant(P<0.05).At 14 days after operation,the edema score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The wound healing time of the observation group was shorter than that of the control group,and the difference was statistically sig

关 键 词：柑橘黄酮片 中药 混合痔 疼痛 愈合 

分 类 号：R657.1[医药卫生—外科学]