用于可控电穿孔的分布式任意波形高压脉冲电源研制  

Development of distributed arbitrary waveform high voltage pulse generator for controllable electroporation

作　　者：刘源浩 李柳霞 刘毅[1] 彭梓皇 高毅凡 林福昌[1] LIU Yuanhao;LI Liuxia;LIU Yi;PENG Zihuang;GAO Yifan;LIN Fuchang(State Key Laboratory of Advanced Electromagnetic Technology,School of Electrical and Electronic Engineering,Huazhong University of Science and Technology,Wuhan 430074,China)

机构地区：[1]华中科技大学电气与电子工程学院强电磁技术全国重点实验室,武汉430074

出　　处：《核技术》2025年第1期92-101,共10页Nuclear Techniques

基　　金：国家自然科学基金青年项目(No.52107151)资助。

摘　　要：针对电穿孔研究与应用对于特殊脉冲波形的需求,本文基于全桥逆变结构的双极性全固态Marx拓扑,提出了一种由多个标准脉冲功率模块组成的分布式任意波形高压脉冲电源。每个标准模块均包含完整的主电路、驱动电路以及控制电路,且内置了通信协议,具有单模块独立工作与多模块组合协同工作等多种工作模式。通过对模块中不同开关的状态进行控制,可以实现任意高压脉冲波形的输出。基于电源-负载匹配分析了关键器件参数对输出的影响,搭建了电源的拓扑仿真模型,验证了其正确性与可行性。在此基础上研制了可输出±8 kV、33阶电平任意波形的实验样机,并搭建出微藻电穿孔实验平台。在控制脉冲电压幅值为8kV、能量为0.4 J条件下进行多种波形的微藻电穿孔实验充分论证了该分布式电源在可控电穿孔领域的适用性。[Background]Electroporation technology can be used in biomedicine,food safety,sewage treatment and other fields.The pulse waveform is an important parameter affecting electroporation efficiency.[Purpose]This study aims to propose a distributed arbitrary waveform high-voltage pulse generator composed of multiple standard pulse power modules to meet the needs of controllable electroporation.[Methods]Firstly,based on full bridge inverter structure,the framework of the distributed generator with bipolar all solid state Marx topology was designed,and the basic working principle of the main circuit of standard module was elaborated.Then,the power and load parameters were simulated and analyzed using Simulink module of MATLAB software.Based on the simulation results,a prototype generator composed of two standard modules in series was built,and the resistance load test was carried out.Finally,under the condition of the same pulse amplitude and pulse energy,the electroporation experiment of microalgae was carried out to verify the correctness and feasibility of high-voltage pulse generator.[Results]The generator can output arbitrary pulse waveform of±8 kV with 33 electrical levels.Under the condition of pulse amplitude 8 kV and pulse energy 0.4 J,the electroporation efficiencies of positive square wave and exponential attenuation wave are 65.25%and 46.15%,respectively.[Conclusions]The applicability of the generator proposed in this study is demonstrated in the controllable electroporation experiment,and the electroporation efficiency of square wave with constant amplitude and energy is higher than that of exponential attenuation wave.

关 键 词：脉冲功率技术 分布式脉冲发生器 任意高压脉冲波形 电穿孔 

分 类 号：TM832[电气工程—高电压与绝缘技术]