低碳水化合物饮食对肥胖型多囊卵巢综合征患者代谢、内分泌指标和妊娠结局的影响  

The Impact of Low⁃Carbohydrate Diet on Endocrine and Pregnancy Out⁃comes in Obesity Patients with PCOS

作　　者：高原 高杨 管桂雪 孙倩 徐金金 杨文 GAO Yuan;GAO Yang;GUAN Guixue;SUN Qian;XU Jinjin;YANG Wen(Department of Gynecology,Nanjing Medical University Kangda College First Affiliated Hospital the First People's Hospital of Lianyungang,Lianyungang,Jiangsu 222004,China;First Clinical College,Xuzhou Medical University,Xuzhou,Jiangsu 221000,China)

机构地区：[1]南京医科大学康达学院第一附属医院连云港市第一人民医院妇科,江苏连云港222004 [2]徐州医科大学第一临床学院,江苏徐州221000

出　　处：《转化医学杂志》2024年第8期1156-1159,1188,共5页Translational Medicine Journal

基　　金：连云港市妇幼健康科研项目(F202103);江苏省妇幼健康科研项目(F202317)。

摘　　要：目的 探讨低碳水化合物饮食对肥胖型多囊卵巢综合征(PCOS)患者代谢指标、内分泌指标及妊娠结局的影响。方法 选择2021年2月至2023年6月收治的肥胖型PCOS患者218例,按就诊号随机数字表法分为试验组(n=109)和对照组(n=109)。试验组采用低碳水化合物饮食,对照组采用常规饮食,均持续8周。比较2组低碳水化合物饮食干预前后基本指标、代谢及内分泌指标,随访观察2组妊娠结局。结果 低碳水化合物饮食干预前,2组年龄、体质量指数(BMI)、体脂率、腰臀比、三酰甘油(TG)、空腹胰岛素(FINS)、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)和尿酸(UA)比较均无差异(P> 0.05)。低碳水化合物饮食干预后,试验组的BMI、体脂率、腰臀比、TG、FINS、AST、ALT、UA均显著低于对照组(P<0.05)。对2组患者随访发现,试验组的总妊娠率明显高于对照组(P<0.05)。结论 对肥胖型PCOS患者进行低碳水化合物饮食干预,能有效降低体质量相关指标,改善代谢及内分泌指标,提高妊娠率。Objective To investigate the effects of low⁃carbohydrate diet on metabolic indexes,endocrine indexes and pregnancy outcomes in obese patients with polycystic ovary syndrome(PCOS).Methods A total of 218 obese PCOS pa⁃tients admitted from February 2021 to June 2023 were divided into experimental group(n=109)and control group(n=109)by random number table method.The experimental group was given a low⁃carbohydrate diet and the control group was given a conventional diet for 8 weeks.The basic indexes,metabolic and endocrine indexes of the two groups were compared before and after the intervention of low⁃carbohydrate diet,and the pregnancy outcomes of the two groups were followed up.Results Be⁃fore low⁃carbohydrate diet intervention,there were no significant differences in age,body mass index(BMI),body fat per⁃centage,waist⁃to⁃hip ratio,triglyceride(TG),fasting insulin(FINS),aspartate aminotransferase(AST),alanine amin⁃otransferase(ALT)and uric acid(UA)between 2 groups(P>0.05).After low⁃carbohydrate diet intervention,BMI,body fat percentage,waist⁃to⁃hip ratio,TG,FINS,AST,ALT and UA in test group were significantly lower than those in control group(P<0.05).The total pregnancy rate in the experimental group was significantly higher than that in the control group(P<0.05).Conclusion Low carbohydrate diet intervention for obese PCOS patients can effectively reduce body mass relat⁃ed indexes,improve metabolic and endocrine indexes,and increase pregnancy rate.

关 键 词：多囊卵巢综合征 低碳水化合物饮食 肥胖 三酰甘油 空腹胰岛素 天冬氨酸转氨酶 丙氨酸转氨酶 尿酸 

分 类 号：R711.75[医药卫生—妇产科学]