卡前列甲酯栓预处理后宫腔镜引导下清宫术联合雌孕激素治疗稽留流产的效果分析  

Effect Analysis of Hysteroscopic Uterine Clearance Combined with Estron in the Treatment of Missed Abortion After Pretreatment with Carboprost Methylate Suppositories

作　　者：龚咪 郁胜胜 张磊 钱二艳 GONG Mi;YU Shengsheng;ZHANG Lei;QIAN Eryan(Department of Gynecology,the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University,Huai'an,Jiangsu 223300,China;Department of Gynecology and obstetrics,Huai'an No.4 People's Hospital,Huai'an,Jiangsu 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院妇科,江苏淮安223300 [2]淮安市第四人民医院妇产科,江苏淮安223300

出　　处：《转化医学杂志》2024年第8期1179-1182,共4页Translational Medicine Journal

基　　金：淮安市基础研究计划(联合专项)卫生健康类科研项目(HABL2023064)。

摘　　要：目的 探讨卡前列甲酯栓预处理后宫腔镜引导下清宫术联合雌孕激素治疗稽留流产患者的效果。方法 筛选2019年1月至2022年1月收治的100例稽留流产患者作为研究对象,按照后续治疗方式不同分为A组与B组,每组50例。A组采用术前卡前列甲酯栓阴道预处理+宫腔镜引导下清宫术+术后雌孕激素口服治疗,B组采用术前卡前列甲酯栓阴道预处理+清宫术+术后雌孕激素口服治疗。分别比较2组的术中及术后相关指标。结果 A组的手术时间长于B组,术中出血量少于B组(P<0.05)。2组术中3次以上宫腔操作率、子宫穿孔率比较差异均无统计学意义(P> 0.05)。A组术后阴道出血时间及术后月经复潮时间短于B组,二次清宫率、宫腔粘连率低于B组(P<0.05)。2组术后盆腔感染发生率比较差异无统计学意义(P> 0.05)。结论 卡前列甲酯栓预处理后采用宫腔镜引导下清宫术联合术后雌孕激素的治疗方式在减少稽留流产患者术后并发症的同时,还能有效减少术中出血量,缩短术后阴道出血时间及术后月经复潮时间,可使患者从中获益。Objective To investigate the effect of hysteroscopic hysteroscopy combined with estrogen in the treatment of missed abortion after pretreatment with Carboprost Methylate Suppositories.Methods A total of 100 missed abortion pa⁃tients admitted from January 2019 to January 2022 were selected as research objects and divided into group A and Group B ac⁃cording to different follow⁃up treatment methods,with 50 cases in each group.Group A received pre⁃operative vaginal pretreat⁃ment with Carboprost Methylate Suppositories+hysteroscopic uterine clearance+postoperative oral estrogen progesterone treat⁃ment;group B received pre⁃operative vaginal pretreatment with Carboprost Methylate Suppositories+uterine clearance+post⁃operative oral estrogen progesterone treatment.The intraoperative and postoperative indexes of the two groups were compared respectively.Results The operative time of group A was longer than that of group B,and the intraoperative blood loss was less than that of group B(P<0.05).There were no significant differences in the rates of more than 3 intrauterine operations and uterine perforation between 2 groups(P>0.05).The postoperative vaginal bleeding time and menstrual rehydrating time in group A were shorter than those in group B,and the rate of second uterine clearance and uterine adhesion were lower than those in group B(P<0.05).There was no significant difference in the incidence of postoperative pelvic infection and other complications between the two groups(P>0.05).Conclusion After pretreatment with Carboprost Methylate Suppositories,hysteroscopic uterine clearance combined with postoperative estron can not only reduce postoperative complications in missed abortion patients,but also effectively reduce intraoperative blood loss,shorten postoperative vaginal bleeding time and postop⁃erative menstrual rehydration time,which can benefit patients.

关 键 词：稽留流产 雌孕激素 宫腔镜检查 卡前列甲酯栓 清宫术 

分 类 号：R714.21[医药卫生—妇产科学]