血清CaN、TNF-α、IFN-γ与川崎病患儿冠状动脉损伤及治疗效果的相关性研究  

The Correlation Between Serum CaN,TNF⁃α,IFN⁃γand Coronary Artery Lesion,Therapeutic Effect in Children with Kawasaki Disease

作　　者：张小平 王俊英 马晓路 ZHANG Xiaoping;WANG Junying;MA Xiaolu(Cardiovascular and Rheumatology Department of Shanxi Provincial Children's Hospital(Shanxi Maternal and Child Health Hos-pital),Taiyuan 030025,China)

机构地区：[1]山西省儿童医院(山西省妇幼保健院)心血管风湿科,太原030025

出　　处：《转化医学杂志》2024年第8期1231-1235,共5页Translational Medicine Journal

基　　金：山西省儿童医院科研课题计划(201952)。

摘　　要：目的研究血清钙调神经磷酸酶(CaN)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)与川崎病(KD)患儿冠状动脉损伤(CAL)及治疗效果的相关性。方法选择2020年4月至2023年8月收治的川崎病患儿114例,选择同期来本院体检的健康儿童36例作为对照组。根据治疗效果分为有反应组和无反应组,检测受试者血清CaN、TNF-α和IFN-γ水平;根据川崎病患儿是否发生CAL分为CAL组和非CAL组,采用超声检查受试者冠状动脉指标,分析血清CaN、TNF-α和IFN-γ联合检测对川崎病患儿治疗效果的预测价值及与冠状动脉内径相关性。结果川崎病患儿血清CaN、TNF-α、IFN-γ水平均显著高于对照组(P<0.01);有反应组患儿血清CaN、TNF-α、IFN-γ水平显著低于无反应组(P<0.01);血清CaN、TNF-α、IFN-γ水平联合预测川崎病患儿治疗效果的曲线下面积最大,敏感度和特异度均最高(P<0.05);CAL组患儿血清CaN、TNF-α、IFN-γ水平显著高于无CAL组(P<0.05);CAL组患儿冠状动脉内径显著高于无CAL组和对照组(P<0.05);血清CaN、TNF-α、IFN-γ水平与冠状动脉内径呈正相关(P<0.05)。结论川崎病患儿血清CaN、TNF-α、IFN-γ水平均升高,与患儿CAL程度密切相关,联合检测血清CaN、TNF-α、IFN-γ水平可预测川崎病的治疗效果。Objective To investigate the correlation of serum calcineurin(CaN),tumor necrosis factor⁃α(TNF⁃α),interferon⁃γ(IFN⁃γ)with coronary artery injury(CAL)and therapeutic effect in children with Kawasaki disease(KD).Methods A total of 114 KD children admitted from April 2020 to August 2023 were selected,and 36 healthy children who came to our hospital for physical examination during the same period were selected as the control group.According to the treat⁃ment effect,the subjects were divided into response group and non⁃response group,and the serum levels of CaN,TNF⁃αand IFN⁃γwere detected.Children with Kawasaki disease were divided into CAL group and non⁃CAL group according to whether CAL occurred.Coronary artery indexes of the subjects were examined by ultrasound,and the predictive value of the combined detection of serum CaN,TNF⁃αand IFN⁃γin the treatment effect of children with Kawasaki disease and its correlation with coronary artery diameter were analyzed.Results The serum levels of CaN,TNF⁃αand IFN⁃γin Kawasaki disease children were significantly higher than those in control group(P<0.01).The levels of serum CaN,TNF⁃αand IFN⁃γin response group were significantly lower than those in non⁃response group(P<0.01).The area under the curve and the sensitivity and specificity of serum CaN,TNF⁃αand IFN⁃γcombined predicted the therapeutic effect of Kawasaki disease children were the highest(P<0.05).The serum levels of CaN,TNF⁃αand IFN⁃γin CAL group were significantly higher than those in no⁃Cal group(P<0.05).The coronary artery diameter in CAL group was significantly higher than that in no⁃CAL group and control group(P<0.05).Serum levels of CaN,TNF⁃αand IFN⁃γwere positively correlated with coronary artery diameter(P<0.05).Conclusion Serum levels of CaN,TNF⁃αand IFN⁃γwere all increased in children with Kawasaki disease,which was closely related to the degree of CAL in children.Combined detection of serum levels of CaN,TNF⁃αand IFN⁃γcould pre⁃di

关 键 词：黏膜皮肤淋巴结综合征 钙调神经磷酸酶 肿瘤坏死因子-Α 干扰素-Γ 冠状动脉损伤 

分 类 号：R543[医药卫生—心血管疾病]