早期妊娠孕妇血清GDF15、preptin水平与孕早期焦虑、抑郁的相关性研究  

Study on the Correlation Between Serum GDF15,preptin Levels and Early Pregnancy Anxiety and Depression in Pregnant Women

作　　者：张燕 武菁菁 韩东香 郁瑞平 ZHANG Yan;WU Jingjing;HAN Dongxiang;YU Ruiping(Department of Obstetrics and Gynecology,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050000,China)

机构地区：[1]石家庄市妇幼保健院妇产科,石家庄050000

出　　处：《转化医学杂志》2024年第8期1261-1265,共5页Translational Medicine Journal

摘　　要：目的探讨孕早期焦虑、抑郁与早期妊娠孕妇血清生长分化因子15(GDF15)、preptin水平的相关性。方法选择2023年11月至2024年3月定期产检的孕早期妇女200例作为研究对象,将其分为焦虑抑郁组124例,正常组76例。采用酶联免疫吸附法(ELISA)测定血清GDF15、preptin表达水平;采用Spearman法分析血清GDF15、preptin表达水平与焦虑自评量表(SAS)和抑郁自评量表(SDS)评分的相关性;采用多因素logistic回归分析影响孕早期妇女焦虑、抑郁的因素。结果焦虑抑郁组和正常组家庭人均月收入、工作生活压力、妊娠意愿比较差异有统计学意义(P<0.05,P<0.01)。与正常组相比,焦虑抑郁组血清GDF15表达水平显著升高,preptin表达水平显著降低(P<0.01)。随着焦虑、抑郁严重程度由轻度到重度逐渐增加,GDF15表达水平逐渐显著升高,preptin表达水平逐渐显著降低,且SAS、SDS评分显著升高(P<0.01)。经Spearman相关性分析结果,血清GDF15与SAS、SDS评分呈正相关性(r=0.447、0.491,P<0.05),血清preptin与SAS、SDS评分呈负相关性(r=-0.424、-0.590,P<0.05)。多因素logistic回归分析结果,preptin是孕早期焦虑抑郁的保护因素,GDF15、家庭人均月收入、工作生活压力、妊娠意愿是孕早期焦虑抑郁的危险因素(P<0.05,P<0.01)。结论孕早期焦虑、抑郁者血清GDF15表达水平升高,preptin表达水平降低,与孕早期焦虑、抑郁严重程度密切相关。Objective To investigate the correlation between anxiety and depression in the first trimester and levels of serum growth differentiation factor 15(GDF15)and preptin.Methods A total of 200 women in the first trimester who had reg⁃ular antenatal check⁃up from November 2023 to March 2024 were selected as the study objects,and they were divided into anxie⁃ty and depression group(124 cases)and normal group(76 cases).The expression levels of GDF15 and preptin in serum were determined by enzyme⁃linked immunosorbent assay(ELISA).The correlation between the expression levels of GDF15 and Prep⁃tin in serum and the scores of self⁃rating Anxiety Scale(SAS)and self⁃rating Depression Scale(SDS)was analyzed by Spearman method.Multivariate logistic regression was used to analyze the influencing factors of anxiety and depression in women in early pregnancy.Results There were significant differences in family per capita monthly income,work⁃life pressure and pregnancy intention between anxiety and depression group and normal group(P<0.05,P<0.01).Compared with normal group,the expression level of GDF15 in anxiety and depression group was significantly increased,and the expression level of preptin was significantly decreased(P<0.01).As the severity of anxiety and depression gradually increased from mild to se⁃vere,the expression level of GDF15 was gradually significantly increased,the expression level of preptin was gradually signifi⁃cantly decreased,and the scores of SAS and SDS were significantly increased(P<0.01).Spearman correlation analysis showed that serum GDF15 was positively correlated with SAS and SDS scores(r=0.447,0.491,P<0.05),and serum preptin was negatively correlated with SAS and SDS scores(r=-0.424,-0.590,P<0.05).Multivariate logistic regression analysis showed that preptin was a protective factor for anxiety and depression in the first trimester,while GDF15,per capita monthly family income,work⁃life pressure and pregnancy intention were risk factors for anxiety and depression in the first trim

关 键 词：焦虑 抑郁 早期妊娠 生长分化因子15 PREPTIN 相关性 

分 类 号：R714[医药卫生—妇产科学]