肛泰软膏联合复方黄柏液涂剂促进肛瘘术后创面恢复的疗效  

Efficacy Evaluation of Promoting Wound Healing after Anal Fistula Sur⁃gery by the Combinate Application of Gangtai Ointment and Compound Huangbai Coating Agent

作　　者：蒋洁 陆杰[1] 王垒 季佩东 钱海华[3] JIANG Jie;LU Jie;WANG Lei;JI Peidong;QIAN Haihua(Department of Colorectal,Nantong Traditional Chinese Medicine Hospital,Nantong,Jiangsu 226000,China;Department of Surgery,Nantong Traditional Chinese Medicine Hospital,Nantong,Jiangsu 226000,China;Department of Colorectal,Jiangsu Provincial Traditional Chinese Medicine Hospital,Jiangsu 210000,Chi-na)

机构地区：[1]南通市中医院肛肠科,江苏南通226000 [2]南通市中医院外科,江苏南通226000 [3]江苏省中医院肛肠科,南京210000

出　　处：《转化医学杂志》2024年第8期1272-1275,共4页Translational Medicine Journal

基　　金：南通市科技局基础研究和社会民生科技计划(指导性项目)(JCZ20090)。

摘　　要：目的探讨肛泰软膏联合复方黄柏液涂剂联合应用对肛瘘术后创面恢复的改善效果。方法选择2018年1月至2023年12月就诊的肛瘘患者80例。根据患者意愿分为对照组和观察组,每组40例。对照组给予肛泰软膏含药纱布条外敷,观察组给予肛泰软膏含药及复方黄柏液涂剂复合纱布条外敷。观察2组术后创面愈合时间、疼痛情况、创面分泌、肉芽生长情况以及白细胞介素-1β(IL-1β)、表皮生长因子(EGF)、血管内皮生长因子(VEGF)表达水平变化。结果观察组术后2、5、10 d创面愈合率优于对照组,术后第5、10天痛感评分低于对照组(P<0.01);2组术后第5、10天创面分泌评分均低于对照组(P<0.01);观察组术后第5、10天肉芽生长情况优于对照组(P<0.01);术后10 d,2组IL-1β表达水平低于术后2 d,EGF、vEGF表达水平均高于术后2 d(P<0.05);观察组术后10 d IL-1β表达水平低于对照组,术后2、10 d EGF、vEGF表达水平均高于对照组(P<0.05)。结论肛泰软膏与复方黄柏液涂剂联合应用对肛瘘术后创面恢复具有积极作用,可以显著缩短患者的术后恢复进程。Objective To investigate the effect of antai ointment combined with compound huangbai liquid coating on wound recovery after anal fistula operation.Methods A total of 80 patients with anal fistula were selected from January 2018 to December 2023.Patients were divided into control group and observation group according to their wishes,with 40 cases in each group.The control group was given Antai ointment containing medicine gauze strip,and the observation group was given Antai ointment containing medicine and compound Huangbai liquid coating compound gauze strip.Postoperative wound healing time,pain,wound secretion,granulation growth and the expression levels of interleukin⁃1β(IL⁃1β),epidermal growth factor(EGF)and vascular endothelial growth factor(VEGF)were observed in the 2 groups.Results The wound healing rate of the observation group was better than that of the control group at 2,5 and 10 days after surgery,and the pain score at 5 and 10 days after surgery was lower than that of the control group(P<0.01).The wound secretion scores of the 2 groups were lower than those of the control group at the 5th and 10th day after surgery(P<0.01).The granulation growth of observation group was bet⁃ter than that of control group at the 5th and 10th day after operation(P<0.01).The expression level of IL⁃1βin 2 groups was lower on day 10 after surgery than on day 2 after surgery,and the expression levels of EGF and vEGF were higher on day 2 after surgery(P<0.05).The expression level of IL⁃1βin the observation group was lower than that in the control group 10 days after surgery,and the expression levels of EGF and vEGF were higher than those in the control group 2 and 10 days after surgery(P<0.05).Conclusion The combined application of Antai ointment and compound Huangbai liquid has a positive effect on wound recovery after anal fistula operation,and can significantly shorten the postoperative recovery process of patients.

关 键 词：肛瘘 复方黄柏液涂剂 创面愈合 白细胞介素-1Β 表皮生长因子 血管内皮生长因子 

分 类 号：R657.1[医药卫生—外科学]