自拟方胃复生治疗湿热瘀阻证慢性萎缩性胃炎临床观察  

Clinical Observation on the Treatment of Chronic Atrophic Gastritis with Dampness⁃heat Stasis with Self⁃prepared Formula Weifusheng

作　　者：魏静波 夏凯 卢川 王笑梅[1] WEI Jingbo;XIA Kai;LU Chuan;WANG Xiaomei(Bengbu Traditional Chinese Medicine Hospital,Bengbu,Anhui 233000,China)

机构地区：[1]蚌埠市中医医院,安徽蚌埠233000

出　　处：《转化医学杂志》2024年第8期1276-1279,共4页Translational Medicine Journal

基　　金：安徽省自然科学基金项目(1908085MH282)。

摘　　要：目的探究自拟方胃复生治疗湿热瘀阻证慢性萎缩性胃炎的疗效。方法选择2022年2月至2023年2月收治的湿热瘀阻证慢性萎缩性胃炎患者60例,按照随机分配法分为观察组和对照组,每组30例。对照组患者服用摩罗丹治疗,观察组患者给予自拟方胃复生治疗。对比2组治疗效果、胃黏膜病理评分、胃功能指标和不良反应发生率。结果观察组治疗有效率[93.33%(28/30)]明显高于对照组[73.33%(22/30)],差异有统计学意义(P<0.05)。观察组治疗后胃黏膜病理评分低于对照组,胃功能指标优于对照组(P<0.05)。观察组治疗期间不良反应发生率明显低于对照组(P<0.05)。结论自拟方胃复生治疗湿热瘀阻证慢性萎缩性胃炎临床效果较好,且不良反应少。Objective To explore the therapeutic effect of self⁃prepared formula Weifusheng on chronic atrophic gas⁃tritis with dampness⁃heat stasis.Methods A total of 60 patients with damp⁃heat stasis chronic atrophic gastritis treated from February 2022 to February 2023 were selected and divided into observation group and control group according to random allo⁃cation method,with 30 cases in each group.The control group was treated with morodin,and the observation group was trea⁃ted with self⁃designed gastrorevivalism.The therapeutic effect,gastric mucosal pathological score,gastric function index and incidence of adverse reactions were compared between the two groups.Results The effective rate of the observation group was 93.33%(28/30),which was significantly higher than that of the control group[73.33%(22/30)],the difference was sta⁃tistically significant(P<0.05).After treatment,the gastric mucosal pathological score of the observation group was lower than that of the control group,and the gastric function index was better than that of the control group(P<0.01).The inci⁃dence of adverse reactions in the observation group was significantly lower than that in the control group(P<0.05).Conclu⁃sion The clinical effect of self⁃prepared formula Weifusheng in the treatment of chronic atrophic gastritis with dampness⁃heat stasis is better,and the side effects are less.

关 键 词：自拟方胃复生 湿热瘀阻证 慢性萎缩性胃炎 胃黏膜萎缩程度 肠上皮异常化生 胃蛋白酶原1 胃蛋白酶原2 胃泌素17 

分 类 号：R459.9[医药卫生—治疗学]