司美格鲁肽联合地屈孕酮对多囊卵巢综合征不孕症患者性激素水平和卵巢功能的影响  

Effects of Semaglutide Combined with Dydrogesterone on Hormone Levels and Ovarian Function in Infertile Patients with Polycystic Ovary Syndrome

作　　者：王颖[1] 白莉 WANG Ying;BAI Li(Department of Gynaecology and Obstetrics,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710000,China)

机构地区：[1]西安交通大学第二附属医院妇产科,西安710000

出　　处：《转化医学杂志》2024年第8期1280-1283,共4页Translational Medicine Journal

基　　金：陕西省重点研发计划项目(2022SF-126)。

摘　　要：目的探讨司美格鲁肽联合地屈孕酮对多囊卵巢综合征(PCOS)不孕症患者性激素水平和卵巢功能的影响。方法回顾性分析2022年5月至2023年5月诊治的PCOS不孕症患者100例的临床资料。按治疗方法分为观察组和对照组,每组50例。对照组给予地屈孕酮治疗,观察组在对照组基础上加用司美格鲁肽。评估2组治疗前后性激素水平、卵巢功能、月经周期及体质量管理指标。结果观察组治疗有效率[94.00%(47/50)]显著高于对照组[80.00%(40/50)],差异有统计学意义(P<0.05)。治疗后,观察组黄体生成素/促卵泡激素比值、卵巢体积、睾酮水平、体质量指数和腰臀比均低于对照组,卵泡数少于对照组,月经周期短于对照组,雌二醇水平高于对照组,子宫内膜厚度大于对照组(P<0.05)。结论司美格鲁肽联合地屈孕酮可有效改善PCOS不孕症患者的性激素水平、卵巢功能及体质量指标。Objective To investigate the effects of Semaglutide combined with desdrogesterone on sex hormone levels and ovarian function in infertility patients with polycystic ovary syndrome(PCOS).Methods The clinical data of 100 pa⁃tients with PCOS infertility diagnosed and treated from May 2022 to May 2023 were retrospectively analyzed.They were divid⁃ed into observation group and control group according to treatment methods,with 50 cases in each group.The control group was treated with Dydrogestone,and the observation group was treated with Semaglutide.Sex hormone levels,ovarian function,menstrual cycle and body mass management indexes were evaluated before and after treatment.Results The effective rate of observation group[94.00%(47/50)]was significantly higher than that of control group[80.00%(40/50)],and the difference was statistically significant(P<0.05).After treatment,luteining⁃hormone/follicle⁃stimulating hormone ratio,ovarian volume,testosterone level,body mass index and waist⁃to⁃hip ratio in observation group were lower than control group,follicle number was lower than control group,menstrual cycle was shorter,estradiol level was higher than control group,and endometrial thickness was higher than control group(P<0.05).Conclusion Smaglutide combined with Dydrogestone can effectively improve the sex hormone levels,ovarian function and body mass indexes of PCOS infertility patients.

关 键 词：司美格鲁肽 地屈孕酮 多囊卵巢综合征 不孕症 黄体生成素 促卵泡激素 雌二醇 卵巢功能 

分 类 号：R711.6[医药卫生—妇产科学]