糖化血清蛋白和糖化血红蛋白联合CA199在2型糖尿病中的早期诊断价值分析  

Analysis of value of glycated serum protein and glycated hemoglobin combined with CA199 in early diagnosis of typeⅡdiabetes mellitus

作　　者：崔媛媛 石梦侠 王茜 CUI Yuan-yuan;SHI Meng-xia;WANG Qian(Department of clinical Laboratory,Kaifeng Central Hospital,Kaifeng,Henan 475000,China)

机构地区：[1]开封市中心医院检验科,河南开封475000

出　　处：《医药论坛杂志》2024年第23期2564-2568,共5页Journal of Medical Forum

摘　　要：目的分析糖化血清蛋白(glycated serum protein,GSP)、糖化血红蛋白(glycated hemoglobin,HbA1c)及糖类抗原199(carbohydrate antigen,CA199)在2型糖尿病(type 2 diabetes mellitus,T2DM)中的早期诊断价值。方法本研究纳入2022年1月至2022年12月在开封市中心医院就诊的106例T2DM患者为观察组,同期健康体检者50例纳入对照组,于清晨收集所有受试者空腹静脉血检测GSP、HbA1c及CA199水平,探讨GSP、HbA1c及CA199水平与T2DM发生发展的关系并分析三者在T2DM中的早期诊断价值。结果与对照组相比,观察组患者GSP、HbA1c及CA199水平均显著升高,差异有统计学意义(P<0.05)。根据观察组患者是否有糖尿病合并症将其分为无并发症组及并发症组,其中无并发症组59例,并发症组47例。与无并发症组相比,并发症组患者GSP、HbA1c及CA199水平均显著升高,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,观察组患者GSP水平与HbA1c水平呈显著正相关(r=0.341,P=0.043);GSP水平与CA199水平呈显著正相关(r=0.515,P=0.036);HbA1c水平与CA199水平呈显著正相关(r=0.374,P=0.027)。GSP、HbA1c及CA199三者联合预测早期T2DM的曲线下面积为0.977(P<0.05),灵敏度为90.57%,特异性为94.00%,95%置信区间为0.9585~0.9963,优于任何一个单独指标的诊断效能。结论GSP、HbA1c及CA199联合检测在T2DM的早期诊断及病情监测中具有较为理想的应用价值。Objective To analyze the value of glycated serum protein(GSP),glycated hemoglobin(HbA1c),and carbohydrate antigen 199(CA199)in the early diagnosis of type 2 diabetes mellitus(T2DM).Methods In this study,106 patients with T2DM treated in Kaifeng Central Hospital from January 2022 to December 2022 were included as the observation group,and 50 healthy subjects were included as the control group during the same period.Fasting venous blood of all subjects was collected in the morning to detect GSP,HbA1c,and CA199 levels.The relationship between GSP,HbA1c,and CA199 levels and the occurrence and development of T2DM was explored,and the early diagnostic value of the three indexes in T2DM was analyzed.Results Compared with control group,the levels of GSP,HbA1c,and CA199 in observation group were significantly increased(P<0.05).The patients in observation group were divided into uncomplicated group and complication group according to whether they had complications or not.There were 59 cases in non-complication group and 47 cases in complication group.Compared with the non-complication group,the levels of GSP,HbA1c,and CA199 in the complication group were significantly increased(P<0.05).Pearson correlation analysis showed that GSP level was significantly positively correlated with HbA1c level in the observation group(r=0.341,P=0.043).GSP level was positively correlated with CA199 level(r=0.515,P=0.036).HbA1c level was positively correlated with CA199 level(r=0.374,P=0.027).The area under the curve of GSP,HbA1c,and CA199 in predicting early T2DM was 0.977(P<0.05),with the sensitivity of 90.57%and the specificity of 94.00%,and the 95%confidence interval was 0.9585-0.9963,which was better than any single index.Conclusion The combined detection of GSP,HbA1c,and CA199 had ideal application value in the early diagnosis and disease monitoring of T2DM.

关 键 词：糖化血清蛋白 糖化血红蛋白 CA199 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]