补肺活血胶囊联合法舒地尔治疗慢性肺源性心脏病稳定期的疗效观察  

Efficacy of Bufei Huoxue Capsules Combined with Fasudil in the Treatment of Pulmonary Heart Disease in Stable Phase

作　　者：阿衣努尔·买买提明 阿里木江·阿不都克里木 努尔阿米娜·买买提吐尔逊 阿布都加帕尔·阿布来提 努日亚·艾尼瓦尔 Ayinuer·MAIMAITIMING;Alimujiang·ABUDUKEREMU;Nueramina·MAIMAITITUERXUN;Abudujiapaer·ABULAITi;Nuerya·AINIWAER(Dept.of Pharmacy,Kashgar the First People’s Hospital,Xinjiang Kashgar 844000,China;Dept.of Pharmacy,Kashgar Uyghur Medical Hospital,Xinjiang Kashgar 844000,China;Dept.of Respiratory and Critical Care Medicine,Kashgar the First People’s Hospital,Xinjiang Kashgar 844000,China)

机构地区：[1]喀什地区第一人民医院药学部,新疆喀什844000 [2]喀什地区维吾尔医医院药剂科,新疆喀什844000 [3]喀什地区第一人民医院呼吸与危重症医学科,新疆喀什844000

出　　处：《中国医院用药评价与分析》2025年第1期45-47,52,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：新疆维吾尔自治区卫生监控委员会青年科研项目(No.WJWY-201967)。

摘　　要：目的:探讨补肺活血胶囊与法舒地尔联合治疗慢性肺源性心脏病稳定期患者的临床疗效。方法:纳入2021年3月至2023年12月喀什地区第一人民医院收治的慢性肺源性心脏病稳定期患者120例,根据随机数字表法分为对照组(采用法舒地尔治疗,n=60)和观察组(采用补肺活血胶囊联合法舒地尔治疗,n=60)。对比两组患者的临床疗效、心功能指标、肺功能指标及不良反应发生情况。结果:治疗后,观察组患者的总有效率为93.33%(56/60),高于对照组的75.00%(45/60),差异有统计学意义(P<0.05)。与对照组比较,观察组患者治疗后左心室射血分数、氧气分压更高,左心房内径、左心室舒张末期内径、肺动脉收缩压、二氧化碳分压更低,差异均有统计学意义(P<0.05)。治疗期间,观察组、对照组患者的不良反应发生率分别为11.67%(7/60)、8.33%(5/60),差异无统计学意义(P>0.05)。结论:补肺活血胶囊与法舒地尔联合治疗可有效提高慢性肺源性心脏病稳定期患者的临床疗效,改善心功能、肺功能,且不增加不良反应。OBJECTIVE:To probe into the clinical efficacy of Bufei Huoxue capsules combined with fasudil in the treatment of patients with pulmonary heart disease in stable phase.METHODS:A total of 120 patients with pulmonary heart disease in stable phase admitted into Kashgar the First People’s Hospital from Mar.2021 to Dec.2023 were enrolled to be divided into the control group(received fasudil,n=60)and observation group(received Bufei Huoxue capsules combined with fasudil,n=60)via random number table method.The clinical efficacy,cardiac function indicators,pulmonary function indicators and incidences of adverse reactions were compared between two groups.RESULTS:After treatment,the total effective rate of the observation group was 93.33%(56/60),higher than 75.00%(45/60)of the control group,with statistically significant difference(P<0.05).Compared with the control group,the left ventricular ejection fraction and oxygen partial pressure were higher,the left atrial diameter,left ventricular end-diastolic dimension,pulmonary arterial systolic pressure and partial pressure of carbon dioxide were lower in the observation group than those in the control group,with statistically significant differences(P<0.05).During treatment,the incidences of adverse reactions of the observation group and the control group were respectively 11.67%(7/60)and 8.33%(5/60),the difference was not statistically significant(P>0.05).CONCLUSIONS:The combination of Bufei Huoxue capsules and fasudil can effectively enhance the clinical efficacy in patients with pulmonary heart disease in stable phase,which can improve cardiac function and pulmonary function,without increasing adverse drug reactions.

关 键 词：补肺活血胶囊 法舒地尔 慢性肺源性心脏病稳定期 疗效 不良反应 

分 类 号：R932[医药卫生—生药学] R972[医药卫生—药学]