瑞芬太尼与舒芬太尼在小儿急性阑尾炎手术中的麻醉效果比较  

Comparison of Anesthetic Effect of Remifentanil and Sufentanil in Acute Appendicitis Surgery in Children

作　　者：孙利红 张晓楠 时建林 冯彦红 马西迁 高素英 SUN Lihong;ZHANG Xiaonan;SHI Jianlin;FENG Yanhong;MA Xiqian;GAO Suying(Dept.of Anesthesia,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050000,China)

机构地区：[1]石家庄市妇幼保健院麻醉科,石家庄050000

出　　处：《中国医院用药评价与分析》2025年第1期57-60,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：河北省卫生健康委员会科研项目(No.20231638)。

摘　　要：目的:比较瑞芬太尼与舒芬太尼在小儿急性阑尾炎手术中的麻醉效果。方法:纳入2022年10月至2023年10月该院收治的急性阑尾炎患儿80例,采用随机数字表法分为对照组和观察组,每组40例。对照组患儿接受丙泊酚+瑞芬太尼静脉麻醉,观察组患儿接受丙泊酚+舒芬太尼静脉麻醉。比较两组患儿在麻醉起效时间、睫毛反射消失时间、疼痛反射消失时间、围手术期指标、血流动力学指标[于麻醉前(T_(1))、麻醉后立即(T_(2))和拔管时(T_(3))监测心率(HR)、血氧饱和度(SaO_(2))及平均动脉压(MAP)]和不良反应等指标上的差异。结果:观察组患儿的麻醉起效时间、睫毛反射消失时间和疼痛反射消失时间较对照组短,差异均有统计学意义(P<0.05)。观察组患儿的术后住院时间、术后首次进餐时间和术后首次下床活动时间短于对照组,差异均有统计学意义(P<0.05)。T_(2)和T_(3)时,观察组患儿的SaO_(2)水平高于对照组;T_(2)时观察组患儿的HR、MAP水平高于对照组,而T_(3)时观察组患儿的HR、MAP水平低于对照组,差异均有统计学意义(P<0.05)。结论:舒芬太尼联合丙泊酚在小儿急性阑尾炎手术中的麻醉效果较好,可改善患儿围手术期指标,稳定术中血流动力学状况,提高术后苏醒质量,无明显不良反应。OBJECTIVE:To compare the anesthetic effect of remifentanil and sufentanil in acute appendicitis surgery in children.METHODS:Totally 80 children with acute appendicitis surgery admitted into the hospital from Oct.2022 to Oct.2023 were extracted to be divided into the control group and observation group via random number table method,with 40 cases in each group.The control group received propofol+remifentanil intravenous anesthesia,while the observation group was given propofol+sufentanil intravenous anesthesia.Differences for onset time of anesthesia,disappearance time of eyelash reflexia,disappearance time of pain reflexia,perioperative indicators,hemodynamic indicators[heart rate(HR),oxygen saturation(SaO_(2))and mean arterial pressure(MAP)were measured before anesthesia(T_(1)),immediately after anesthesia(T_(2)),and during extubation(T_(3))]and adverse drug reactions of two groups were compared.RESULTS:The onset time of anesthesia,disappearance time of eyelash reflexia,and disappearance time of pain reflexia in observation group were shorter than that in control group,with statistically significant differences(P<0.05).The postoperative length of stay,the first meal time and the first activity time of observation group were shorter than those of control group,with statistically significant differences(P<0.05).At T_(2) and T3,the SaO_(2) level in observation group was higher than that in the control group;at T_(2),the HR and MAP levels of observation group were higher than those of control group,while at T_(3),the HR and MAP levels of observation group were lower than those of control group,with statistical significant differences(P<0.05).CONCLUSIONS:Sufentanil combined with propofol has significant anesthetic effect in children with acute appendicitis surgery,which can improve perioperative indicators,stabilize intraoperative hemodynamics,and improve postoperative recovery quality without obvious adverse drug reactions.

关 键 词：舒芬太尼 丙泊酚 小儿急性阑尾炎 血氧饱和度 平均动脉压 

分 类 号：R971.2[医药卫生—药品]