注射用乌司他丁治疗急性循环衰竭的快速卫生技术评估  

Rapid Health Technology Assessment of Urinastatin for Injection in the Treatment of Acute Circulatory Failure

作　　者：郑子恢[1] 高峰 李文英[1] 原涵[1] 张白歌 金鹏飞[1] ZHENG Zihui;GAO Feng;LI Wenying;YUAN Han;ZHANG Baige;JIN Pengfei(Dept.of Pharmacy,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application(Beijing Hospital),Beijing 100730,China;Dept.of Health Service,the Guard Bureau of the Joint Staff Department,Central Military Commission,People’s Republic of China,Beijing 100173,China)

机构地区：[1]北京医院药学部,国家老年医学中心,中国医学科学院老年医学研究院,北京市药物临床风险与个体化应用评价重点实验室(北京医院),北京100730 [2]中央军委联合参谋部警卫局卫生保健处,北京100173

出　　处：《中国医院用药评价与分析》2025年第1期81-84,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：首都卫生发展科研专项(No.首发2024-1-4052)。

摘　　要：目的:评价注射用乌司他丁(UTI)治疗急性循环衰竭(ACF)的有效性、安全性及经济性,为临床合理用药提供循证依据。方法:在PubMed、the Cochrane Library、Embase、万方数据库、中国知网、中国生物医学文献数据库以及卫生技术评估(HTA)机构官方网站中进行检索,收集关于UTI治疗ACF的系统评价/Meta分析、经济学研究及HTA报告,检索时间为建库至2024年6月。由2名研究者根据纳入与排除标准独立进行文献筛选、质量评价和数据提取。结果:共纳入5篇文献,均为Meta分析,未检索到经济学研究及HTA报告。目前纳入的研究在有效性方面选择炎症介质、多器官功能障碍综合征发生率、肝肾功能指标、心功能及死亡率等指标进行分析,联合应用UTI治疗ACF较单纯使用常规治疗具有明显优势,能显著降低炎症介质水平、改善器官损伤。结论:UTI用于ACF的治疗效果确切,安全性良好。OBJECTIVE:To evaluate the efficacy,safety and economy of ulinastatin for injection(UTI)in the treatment of acute circulatory failure(ACF),so as to provide evidence-based evidence for clinical rational drug use.METHODS:PubMed,the Cochrane Library,Embase,Wanfang Data,CNKI,CBM and the official website of the health technology assessment(HTA)were retrieved to collect the systematic evaluation/Meta-analysis,economic evaluation and HTA reports of UTI in the treatment of ACF.The retrieval time was from the establishment of the database to Jun.2024.Literature screening,quality evaluation and data extraction were performed independently by two researchers according to inclusion and exclusion criteria.RESULTS:A total of 5 articles were included,all of which were Meta-analysis,no economic research and HTA report were retrieved.In terms of effectiveness,the included studies selected inflammatory mediators,incidence of multiple organ dysfunction syndrome,liver and kidney function indicators,heart function and mortality for analysis.Compared with conventional treatment alone,the combined application of UTI in the treatment of ACF had significant advantages,which could significantly reduce the level of inflammatory mediators and improve organ damage.CONCLUSIONS:UTI is effective and safe in the treatment of ACF.

关 键 词：乌司他丁 急性循环衰竭 快速卫生技术评估 循证学评价 

分 类 号：R979.9[医药卫生—药品]