万古霉素持续给药在儿童感染中的研究进展  

Progress of Continuous Administration of Vancomycin in Children with Infections

作　　者：果茵茵[1] 党翔吉 何囡囡 曹雯[2] GUO Yinyin;DANG Xiangji;HE Nannan;CAO Wen(Dept.of Pharmacy,the Second Hospital of Lanzhou University,Lanzhou 730030,China;Intensive Care Unit,the Second Hospital of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院药剂科,兰州730030 [2]兰州大学第二医院重症医学科,兰州730030

出　　处：《中国医院用药评价与分析》2025年第1期125-128,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：甘肃省自然科学基金资助项目(No.23JRRA1622,No.20JR10RA749);兰州大学第二医院“萃英科技创新”计划项目(No.CY2022-MS-A15)。

摘　　要：万古霉素属于糖肽类抗菌药物,用于革兰阳性菌感染的治疗。持续性给予万古霉素是一种较新的给药方法。近年来,持续性给药的优点已在成人中获得了较好的验证,其既能保证血药浓度尽早达标,又能减少肾毒性的发生。儿童的万古霉素药动学具有较大变异,导致间歇性给予万古霉素后个体间血药浓度差异过大,因此,持续性给予万古霉素在儿童中可能存在一定的优势。针对持续性给药方式是否适合儿童的问题,本文对目前的相关研究文献及个案报道进行综述。Vancomycin is the glycopeptide antibiotic used in the treatment of Gram-positive bacteria infections.Continuous administration of vancomycin is a relatively new method of administration.In recent years,the advantages of continuous administration have been well verified in adults,which can not only ensure that the blood concentration reaches the standard as soon as possible,but reduce the occurrence of renal toxicity.The pharmacokinetics of vancomycin in children are highly variable,resulting in a large blood drug level difference between individuals after intermittent vancomycin administration.Therefore,continuous administration of vancomycin may have certain advantages in children.This article reviews the current literature and case reports on the suitability of continuous administration in children.

关 键 词：万古霉素 给药方式 持续性给药 间歇性给药 儿童 

分 类 号：R978.1[医药卫生—药品]