钯催化Heck反应研究进展  

Recent Progress of Palladium-Catalyzed Heck Reaction

作　　者：周帅康 宋颖 ZHOU Shuaikang;SONG Ying

机构地区：[1]南宁师范大学化学与材料学院,广西南宁530001

出　　处：《化工设计通讯》2025年第1期12-15,共4页Chemical Engineering Design Communications

基　　金：国家自然科学基金项目(22161031);广西青年人才专项(AD20297018)。

摘　　要：Heck反应是一类构建新的C-C键的重要合成方法,近年来随着新的高活性配体的发展,Heck反应取得了突破性的进展,一些结构复杂以及具有两个手性中心的杂环化合物被高选择性地合成,这一反应成功地应用于合成复杂天然产物和药物分子。从分子内和分子间两方面综述了十几年来钯催化的Heck反应,同时对该领域未来的发展作出了展望。Heck reaction is an important synthesis method for constructing new C-C bonds.In recent years,with the development of new highly active ligands,breakthrough progress has been made in Heck reaction.Some heterocyclic compounds with complex structures and two chiral centers have been highly selectively synthesized,and this reaction has been successfully applied to the synthesis of complex natural products and drug molecules.The Heck reaction catalyzed by palladium in the last decade is reviewed from intramolecular and intermolecular aspects,and the future development of this field is prospected.

关 键 词：钯 HECK反应 C-C键偶联 配体 催化 

分 类 号：TQ203.2[化学工程—有机化工]