P507浸渍的聚苯乙烯与聚丙烯酸酯树脂分离Yb/Lu的对比研究  

Comparative Study of P507-impregnated Polystyrene and Polyacrylate Resins for Separation of Yb/Lu

作　　者：樊锡胜 马国权 彭海岳 高靖 李飞泽[1] 兰图 廖家莉[1] 杨远友[1] 刘宁[1] FAN Xisheng;MA Guoquan;PENG Haiyue;GAO Jing;LI Feize;LAN Tu;LIAO Jiali;YANG Yuanyou;LIU Ning(Key Laboratory of Radiation Physics and Technology of Ministry of Education,Institute of Nuclear Science and Technology,Sichuan University,Chengdu 610064,China)

机构地区：[1]四川大学原子核科学技术研究所辐射物理及技术教育部重点实验室,四川成都610064

出　　处：《原子能科学技术》2025年第1期24-34,共11页Atomic Energy Science and Technology

基　　金：国家自然科学基金(U2067211)。

摘　　要：^(177)Lu特别是无载体(NCA)177Lu在全球范围内的稳定供应问题变得尤为突出。目前,国内用于NCA^(177)Lu生产的LN2树脂有国产和也有进口产品,尽管二者高度相似,但两种LN2树脂的NCA^(177)Lu分离性能是否存在差异仍未形成统一认识,其最佳分离工艺流程也需要进一步优化。为此,本文开展了两种树脂的对比实验。通过多种表征手段对国产和进口LN2树脂的结构和组分等进行了系统分析,在此基础上通过静态吸附实验考察了两种材料对Yb/Lu的吸附性能差异,随后开展了二者动态柱分离Yb/Lu的对比研究,探讨了不同淋洗条件对NCA^(177)Lu分离性能的影响。此外还通过模拟工况下的分离实验研究,为每种树脂优化出了最佳淋洗方案。结果表明,国产与进口树脂的载体分别为聚苯乙烯和聚丙烯酸酯,前者具有更高的萃取剂负载量(质量分数为30.6%),Yb^(3+)和Lu^(3+)静态吸附量更高,但过高的负载量堵塞了树脂孔道,使其在动态柱实验中无法实现Yb/Lu的有效分离,带来了诸如分离度低、淋洗体积大等问题。与文献报道一致的是,进口LN2树脂的分离性能优异,在相对简单的条件下便可实现良好的分离(R_(S)=1.8)。In recent years,target radionuclide therapy(TRT)has developed rapidly in cancer treatment.Among all available medical radionuclides,^(177)Lu is one of the most promising nuclides due to its excellent nuclear properties,with related nuclide-labeled drugs achieving great success in the past decade.With the more rapid development and increasingly wider application of^(177)Lu-labeled drugs,the demand for no carrier added(NCA)^(177)Lu will increase dramatically,making stable supply of^(177)Lu become an ignorable issue.At present,the core problem in the commercial production of NCA^(177)Lu is the separation of 176Yb/^(177)Lu.The solvent-impregnated-resin method is the most mature and widely used method in the production of NCA^(177)Lu,and the crucial functional material is the LN2 resin developed by Triskem(France).In fact,the excellent separation performance makes LN2 resin almost be monopolized in the relevant separation process internationally.Although there are some LN2 resin analogues on sale in China currently,the comparability of its real separation ability with imported LN2resin is still unknown,and their optimal separation process flow needs to be further optimized.To this end,the structures and compositions of domestic and imported LN2 resins were systematically analyzed by SEM,TEM,FT-IR and other characterizations.On this basis,the adsorption and separation performance of the two materials to Yb/Lu was investigated by static adsorption experiments and dynamic column separation,and the effects of different elution conditions on the separation performance of NCA^(177)Lu were investigated.Finally,the optimal nuclide separation performance was optimized for each kind of LN2 resin by simulated real work experiments.Finally,the best nuclide separation scheme was optimized for each resin under simulated working conditions.It is confirmed that the microstructure,extractant loading and nuclide separation performance of imported and domestic LN2 resins are significantly different.The results show that the supporters o

关 键 词：负载量 浸渍树脂 Yb/Lu分离 ^(177)Lu 

分 类 号：TL92[核科学技术—核燃料循环与材料]