Nanoarchitectonics of point-of-care diagnostics for sweat biomarkers analysis  

作　　者：Xuan Lin Arya Vasanth Aditya Ashok Hoang-Phuong Phan Kevin M.Koo Mohammed A.Amin Yusuf Valentino Kaneti Carlos Salomon Md Shahriar A.Hossain Yusuke Yamauchi Mostafa Kamal Masud 

机构地区：[1]School of Chemistry and Molecular Biosciences,The University of Queensland,Brisbane,QLD,4072,Australia [2]Australian Institute of Bioengineering and Nanotechnology,The University of Queensland,Brisbane,QLD,4076,Australia [3]Graduate School of Biomedical Engineering,The University of New South Wales,Sydney,NSW,2052,Australia [4]The University of Queensland Centre for Clinical Research(UQCCR),Herston,Queensland,4029,Australia [5]Department of Chemistry,College of Science,Taif University,P.O.Box 11099,Taif,21944,Saudi Arabia [6]Translational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group,University of Queensland Centre for Clinical Research,Faculty of Medicine,The University of Queensland,Brisbane,QLD 4029,Australia [7]School of Mechanical and Mining Engineering,Faculty of Engineering,Architecture and Information Technology(EAIT),The University of Queensland,Brisbane,QLD,4072,Australia [8]Department of Materials Process Engineering,Graduate School of Engineering,Nagoya University,Furo-cho,Chikusa-ku,Nagoya,Aichi,464-8603,Japan [9]Department of Chemical and Biomolecular Engineering,Yonsei University,Seoul 03722,South Korea

出　　处：《Nano Materials Science》2024年第6期647-671,共25页纳米材料科学(英文版)

基　　金：supported by the JSPS fellowship to M.K.M(Grant Number P20039);support from JST-ERATO Yamauchi Materials Space-Tectonics Project(JPMJER2003);the funding from the Queensland government through the Advance Queensland Fellowship Program(AQIRF043-2020-CV);supported by the National Health and Medical Research Council(NHMRC,1195451).

摘　　要：Sweat contains numerous vital biomarkers such as metabolites,electrolytes,proteins,nucleic acids and antigens that reflect hydration status,exhaustion,nutrition,and physiological changes.Conventional healthcare diagnosis relies on disease diagnostics in sophisticated centralized laboratories with invasive sample collection(e.g.,chemical analyses,plasma separation via centrifugation,tissue biopsy,etc.).Cutting-edge point-of-care diagnostics for sweat biomarker analysis allow for non-invasive monitoring of physiologically related biomarkers in sweat and real-time health status tracking.Moreover,using advanced nanoarchitectures,including nanostructured platforms and nanoparticles,can enhance the specificity,sensitivity,wearability and widen the sensing modality of sweat biosensors.Herein,we comprehensively review the secretory mechanisms,clinical uses of sweat biomarkers,and the design,principle,and latest technologies of sweat biosensors.With an emphasis on cutting-edge technologies for sweat biomarker analysis,this review chronicles the issues associated with the current sweat biomarkers analysis of sweat biomarkers and provides insights into strategies for enhancing the translation of such biosensors into routine clinical practice.

关 键 词：Sweat biomarker Nanoarchitectonics NANOSTRUCTURES Sweat biosensor Point-of-care diagnostics Wearable sweat sensor 

分 类 号：TG1[金属学及工艺—金属学]