心房颤动与β_(2)微球蛋白之间的相关性研究  

Correlation between atrial fibrillation and beta2 microglobulin

作　　者：陈旭[1] 张志宇 杨博 任飞霏 李广平[4] CHEN Xu;ZHANG Zhi-yu;YANG Bo;REN Fei-fei;LI Guang-ping(Department of Cardiology,Beichen Hospital of Nankai University,Tianjin 300400,China;不详)

机构地区：[1]南开大学附属北辰医院心内科,天津300400 [2]天津市北辰区疾病预防控制中心环境健康与学校卫生科 [3]北京卫戍区东城第三离职干部休养所 [4]天津医科大学第二医院心内科

出　　处：《环境与健康杂志》2024年第12期1082-1087,共6页Journal of Environment and Health

摘　　要：目的通过临床资料研究心房颤动(atrial fibrillation,AF)与β_(2)微球蛋白(beta 2-microglobulin,β_(2)-MG)之间的相关性,以期为临床AF诊治提供参考价值。方法根据纳入排除标准收集在天津市某三甲医院2022年9月至2023年12月期间在心内科住院的患者142例,分为除外冠心病的AF组70例和造影正常的对照组72例,比较两组间的血、尿β_(2)-MG、程序性细胞死亡因子4(programmed cell death factor 4,PDCD4)、转化生长因子(transforming growth factor-β_(1),TGF-β_(1))及心脏超声等各指标。结果AF组与对照组在年龄、性别、民族、吸烟史、饮酒史、高血压病史、糖尿病史、高脂血症病史、家族遗传史、肥胖等方面差异无统计学意义(P>0.05);在利伐沙班、达比加群酯、华法林等抗凝药物以及胺碘酮的使用方面更多(P<0.05);在β受体阻滞剂(β-blocker)、离子拮抗剂(CCB)、血管紧张素转换酶抑制剂/血管紧张素受体拮抗剂(ACEI/ARB)、阿司匹林、他汀类药物及索他洛尔的使用方面差异无统计学意义(P>0.05);在血糖指标方面差异无统计学意义(P>0.05);在总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDLc)、低密度脂蛋白胆固醇(low density liptein cholesterol,LDLc)、极低密度脂蛋白胆固醇(very low density liptein cholesterol,VLDLc)、动脉粥样硬化指数(low density liptein/high density liptein,LDL/HDL)等血脂指标方面差异无统计学意义(P>0.05),而LDLc指标差异有统计学意义(P<0.05);在室间隔厚度、左室舒张末内径、左室收缩末内径、左室后壁厚度、右室前壁厚度、右室舒张末内径、主动脉瓣环内径、主动脉瓣开内径、肺动脉内径、射血分数、二尖瓣血流等心脏超声指标方面差异无统计学意义(P>0.05),而左房内径指标差异有统计学意义(P<0.05);在血β_(2)-MG、尿β_(2)-MG、TGF-β_(1)、PDCD4等临床指标方面AF组�Objective To understand the correlation between atrial fibrillation(AF)andβ_(2)microglobulin(beta2-microglobulin,β_(2)-MG)through three parts of clinical data research,and to provide the reference value in diagnosis and treatment.Methods According to the inclusion and exclusion criteria,142 patients who were hospitalized in the cardiology department of a hospital in Tianjin from September 2022 to December 2023 were collected and divided into 70 cases of AF except for coronary heart disease and 72 cases of control group with normal angiography.Blood,urineβ_(2)-MG,PDCD4,TGF-β_(1)and cardiac ultrasound were compared between the two groups.Results Compared with the control group,in AF group no significant differences were seen in age,gender,ethnicity,smoking history,drinking history,hypertension history,diabetes history,hyperlipidemia history,family genetic history and obesity,etc.(P>0.05),and more anticoagulants were used such as rivaroxaban,dabigatran etexilate,warfarin and amiodarone(P<0.05),and no significant differences were seen in use of beta-blockers(β-blockers),ion antagonists(CCB),tubulotensin converting enzyme inhibitors/tubulotensin receptor antagonists(ACEI/ARB),aspirin,statins and sotalol(P>0.05).There was no statistically significant difference in blood glucose(GLU)indexes(P>0.05).No significant differences were seen between the two groups in total cholesterol(TC),triglyceride(TG),high density liptein cholesterol(HDLc),low density liptein cholesterol(LDLc),very low density liptein cholesterol(VLDLc),atherosclerosis index(low density liptein/high density liptein,LDL/HDL)and other blood lipid indexes(P>0.05),but there was a significant difference in LDLc indexes(P<0.05).There was no significant differences in ventricular septal thickness,left ventricular end-diastolic diameter,left ventricular endsystolic diameter,left ventricular posterior wall thickness,right ventricular anterior wall thickness,right ventricular end-diastolic diameter,aortic annulus diameter,aortic valve opening diameter,pulmonary

关 键 词：心房颤动 β_(2)-微球蛋白 程序性细胞死亡因子4 转化生长因子 

分 类 号：R994.6[医药卫生—毒理学] R181.3[医药卫生—药学]