下呼吸道肺炎支原体感染患者血清CRP和PCT以及IL-6水平变化及临床意义  

Changes and clinical significance of serum levels of CRP,PCT and IL-6 in patients with lower respiratory tract infection caused by Mycoplasma pneumoniae

作　　者：许雪琴 黄衍运 吴海霞 李雪华 Xu Xueqin;Huang Yanyun;Wu Haixia;Li Xuehua(Department of Clinical Laboratory,People's Hospital of Yuancheng District,Heyuan City,Heyuan 517000,Guangdong,China)

机构地区：[1]河源市源城区人民医院检验科,广东河源517000

出　　处：《实用检验医师杂志》2024年第4期307-310,共4页Chinese Journal of Clinical Pathologist

基　　金：广东省河源市科技计划项目(河科社农社发2023010)。

摘　　要：目的探讨下呼吸道肺炎支原体感染患者血清CRP、PCT、IL-6水平变化及临床意义。方法选择河源市源城区人民医院2023年5月—2024年5月收治的50例下呼吸道肺炎支原体感染患者作为研究对象,纳入试验组;根据病情严重程度将试验组患者分为轻症组(35例)和重症组(15例);另外选择同期50例在该院参与体检的健康体检者纳入对照组。使用电化学发光免疫分析仪检测白细胞介素-6(IL-6),采用免疫比浊法测定C-反应蛋白(CRP),使用电化学发光免疫分析仪测定降钙素原(PCT);比较试验组和对照组以及不同病情严重程度下呼吸道肺炎支原体感染患者上述指标的水平差异。结果试验组的CRP、PCT、IL-6水平均显著高于对照组〔CRP(mg/L):8.17±0.94比3.52±0.44;PCT(ng/L):2.04±0.34比0.45±0.11;IL-6(μg/L):49.42±5.45比21.36±2.58;均P<0.05〕;重症组患者的CRP、PCT、IL-6水平均显著高于轻症组〔CRP(mg/L):8.27±0.92比7.24±0.76;PCT(ng/L):2.14±0.26比1.95±0.21;IL-6(μg/L)50.59±5.67比43.25±4.67;均P<0.05〕。结论下呼吸道肺炎支原体感染患者进行CRP、PCT、IL-6水平检测可为疾病诊断和病情严重程度评估提供一定参考依据,值得在临床推广应用。Objective To investigate the changes and clinical significance of serum levels of CRP,PCT and IL-6 in patients with lower respiratory tract infection caused by Mycoplasma pneumoniae.Methods Fifty patients with lower respiratory tract infection caused by Mycoplasma pneumoniae admitted in People's Hospital of Yuancheng District,Heyuan City from May 2023 to May 2024 were selected as research subjects and included in experimental group,and the patients in experimental group were divided into mild group(35 cases)and severe group(15 cases)based on the severity of their condition.Other fifty patients who participated in health examinations during the same period were included in control group.Electrochemiluminescence immunoassay was used to detect the level of interleukin-6(IL-6),immunoturbidimetry was used to detect the level of C-reactive protein(CRP),and electrochemiluminescence immunoassay was used to detect the level of procalcitonin(PCT).The differences in the levels of above indicators between experimental group and control group,and among patients with different severity levels of lower respiratory tract infection caused by Mycoplasma pneumoniae were compared.Results The levels of CRP,PCT and IL-6 in experimental group were significantly higher than those in control group[CRP(mg/L):8.17±0.94 vs.3.52±0.44;PCT(ng/L):2.04±0.34 vs.0.45±0.11;IL-6(μg/L):49.42±5.45 vs.21.36±2.58;all P<0.05].The levels of CRP,PCT and IL-6 in severe group were significantly higher than those in mild group[CRP(mg/L):8.27±0.92 vs.7.24±0.76;PCT(ng/L):2.14±0.26 vs.1.95±0.21;IL-6(μg/L):50.59±5.67 vs.43.25±4.67;all P<0.05].Conclusions The detection of CRP,PCT and IL-6 levels in patients with lower respiratory tract infection caused by Mycoplasma pneumoniae could provide certain reference for disease diagnosis and severity evaluation,and is worthy of clinical promotion and application.

关 键 词：下呼吸道感染 肺炎支原体 C-反应蛋白 降钙素原 白细胞介素-6 

分 类 号：R72[医药卫生—儿科]