尿NAG和微量白蛋白检测对泌尿系结石早期肾损伤监测的临床价值  

Clinical value of urinary NAG and microalbumin detection in monitoring early renal injury combined with urinary calculi

作　　者：王桂林 Wang Guilin(Department of Urology,Pucheng County Hospital,Nanping 353400,Fujian,China)

机构地区：[1]浦城县医院泌尿外科,福建南平353400

出　　处：《实用检验医师杂志》2024年第4期324-327,共4页Chinese Journal of Clinical Pathologist

摘　　要：目的分析泌尿系结石早期肾损伤监测中尿N-乙酰β-D氨基葡萄糖苷酶(NAG)和微量白蛋白(mALB)检测的临床价值。方法选择2021年2月—2023年2月浦城县医院收治的100例泌尿系结石患者作为研究对象,根据是否合并早期肾损伤分为合并症组(40例)和无合并症组(60例)。采用硝基苯底物比色法检测尿NAG,采用免疫比浊法检测尿mALB。为减少尿液浓缩或稀释影响检测结果,所有尿液标本均同时检测肌酐(Cr),计算NAG/Cr、mALB/Cr比值。统计并分析两组尿NAG、mALB、Cr水平以及NAG/Cr、mALB/Cr比值差异,比较合并症组尿NAG、mALB单独与联合检测的阳性率。结果合并症组患者的尿NAG、mALB、Cr水平以及NAG/Cr、mALB/Cr比值均显著高于无合并症组〔NAG(U/L):9.51±1.34比7.90±1.10;mALB(mg/L):154.42±9.45比39.06±6.32;Cr(mol/L):8.22±1.50比3.25±1.02;NAG/Cr(U/mol):1.40±0.15比1.07±0.31;mALB/Cr(mg/mol):21.75±3.75比5.37±1.35;均P<0.05〕。合并症组患者尿NAG与mALB联合检测的阳性率显著高于各指标单独检测〔90.00%(36/40)比75.00%(30/40)、67.50%(27/40),均P<0.05〕。结论在泌尿系结石早期肾损伤监测中,尿NAG、mALB均可以作为敏感指标,两项联合检测的临床价值较单独检测高。Objective To analyze the clinical value of detection of urinary N-acetylβ-D-glucosaminidase(NAG)and microalbumin(mALB)in monitoring of early renal injury combined with urinary calculi.Methods The 100 patients with urinary calculi admitted to Pucheng County Hospital from February 2021 to February 2023 were selected as research subjects.They were divided into comorbidity group(40 cases)and no comorbidity group(60 cases)based on whether they had early kidney injury.The level of urinary NAG was detected using nitrobenzene substrate colorimetric method,and the level of urinary mALB was detected using immunoturbidimetric method.To reduce the impact of urine concentration or dilution on the detection results,creatinine(Cr)was simultaneously detected in all urine samples,and NAG/Cr and mALB/Cr ratios were calculated.The differences in levels of urine NAG,mALB,Cr,and NAG/Cr,mALB/Cr ratios were statistically analyzed between two groups,and the positive rates of urine NAG and mALB detected separately and in combination were compared in comorbidity group.Results The levels of urinary NAG,mALB,Cr and NAG/Cr,mALB/Cr ratios in comorbidity group were significantly higher than those in no comorbidity group[NAG(U/L):9.51±1.34 vs.7.90±1.10;mALB(mg/L):154.42±9.45 vs.39.06±6.32;Cr(mol/L):8.22±1.50 vs.3.25±1.02;NAG/Cr(U/mol):1.40±0.15 vs.1.07±0.31;mALB/Cr(mg/mol):21.75±3.75 vs.5.37±1.35;all P<0.05].The positive rate of combined detection of urinary NAG and mALB in comorbidity group was significantly higher than those of individual detection[90.00%(36/40)vs.75.00%(30/40),67.50%(27/40),both P<0.05].Conclusion Urinary NAG and mALB could both be used as sensitive indicators in monitoring of early renal injury combined with urinary calculi,and the clinical value of combined detection is higher than that of individual detection.

关 键 词：泌尿系结石 早期肾损伤 N-乙酰β-D氨基葡萄糖苷酶 微量白蛋白 单独检测 联合检测 临床价值 

分 类 号：R58[医药卫生—内分泌]