住院2型糖尿病患者维生素D及维生素K2的分布及影响因素  

Distribution and influencing factors of vitamin D and vitamin K2 in hospitalized type 2 diabetes patients

作　　者：李小娥 华纯山 唐巧真 庞娟娟 吴加云 李丽萍 李中川 刘梅 Li Xiao'e;Hua Chunshan;Tang Qiaozhen;Pang Juanjuan;Wu Jiayun;Li Liping;Li Zhongchuan;Liu Mei(Department of Endocrine,Weishan County People's Hospital,Jining 277600,Shandong,China)

机构地区：[1]微山县人民医院内分泌科,山东济宁277600

出　　处：《实用检验医师杂志》2024年第4期337-341,共5页Chinese Journal of Clinical Pathologist

基　　金：中华国际科学交流基金会检验检测科技专项基金(Z2021LSD007);山东省济宁市重点研发计划项目(2023YXNS079)。

摘　　要：目的探讨2型糖尿病(T2DM)患者维生素D(VitD)和维生素K2(VitK2)的分布、影响因素以及与代谢指标的相关性。方法回顾并分析微山县人民医院2021年4月—2023年4月收治的344例住院T2DM患者的临床资料。检测总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(APOA1)、VitD、VitK2,血肌酐(SCr)、尿酸(UA)、球蛋白(GLO),白蛋白(ALB)、总胆汁酸(TBA)、促甲状腺激素(TSH)、游离甲状腺素(FT_(4))、糖化血红蛋白(HbA1c)水平;分析VitD及VitK2在T2DM患者中的分布,应用多元线性回归分析其影响因素;采用Spearman相关分析法考察VitD和VitK2与代谢指标的相关性。结果344例住院T2DM患者中,VitD水平适宜的有87例(25.29%),VitK2水平适宜的有57例(16.57%)。男性患者VitD与FT_(4)呈负相关(r值为-0.222,P值为0.003),与TG、ALB均呈正相关(r值分别为0.157、0.381、P值分别为0.032、<0.001);VitK2与年龄呈负相关(r值为-0.243,P值为0.001),与TG、TBA均呈正相关(r值分别为-0.354、0.257,P值分别为<0.001、0.001)。女性患者VitD与体质量指数(BMI)、ALB均呈正相关(r值分别为0.247、0.197,P值分别为0.018、0.020),VitK2与TG、TBA均呈正相关(r值分别为0.333、0.296,P值分别为<0.001、0.001)。影响住院T2DM患者VitD的因素有BMI、FT_(4)、ALB、性别,影响VitK2的因素有TG、TBA和性别。结论VitD、VitK2在住院T2DM患者中普遍缺乏,女性较男性更明显。BMI和ALB为VitD的有利因素,TG和TBA为VitK2的有利因素,性别对VitD、VitK2均有影响。Objective To explore the distribution and influencing factors of vitamin D(VitD)and vitamin K2(VitK2)and the correlation with metabolic indicators in patients with type 2 diabetes mellitus(T2DM).Methods The clinical data of 344 hospitalized T2DM patients in Weishan County People's Hospital from April 2021 to April 2023 were reviewed and analyzed.The levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),apolipoprotein A1(APOA1),VitD,VitK2,serum creatinine(SCr),uric acid(UA),globulin(GLO),albumin(ALB),total bile acid(TBA),thyroid stimulating hormone(TSH),free thyroxine(FT_(4))and glycated hemoglobin(HbA1c)were detected.The distribution of VitD and VitK2 in T2DM patients was analyzed,the multiple linear regression analysis was applied to explore the influencing factors,and the correlation with metabolic indicators was analyzed by Spearman correlation analysis.Results Among 344 hospitalized T2DM patients,87 cases(25.29%)had suitable VitD and 57 cases(16.57%)had suitable VitK2.In male,VitD was negatively correlated with FT_(4)(r=-0.222,P=0.003)and positively correlated with TG and ALB(r=0.157,0.381;P=0.032,<0.001),VitK2 was negatively correlated with age(r=-0.243,P<0.001)and positively correlated with TG and TBA(r=-0.354,0.257;P<0.001,=0.001).In female,VitD was positively correlated with body mass index(BMI)and ALB(r=0.247,0.197;P=0.018,0.020),VitK2 was positively correlated with TG and TBA(r=0.333,0.296;P<0.001,=0.001).In hospitalized T2DM patients,the factors affecting VitD included BMI,FT_(4),ALB and gender,and the factors affecting VitK2 were TG,TBA and gender.Conclusions VitD and VitK2 are generally insufficient in hospitalized T2DM patients,with female being more pronounced than male.BMI and ALB are favorable factors for VitD,and TG and TBA are favorable factors for VitK2.

关 键 词：维生素D 维生素K2 2型糖尿病 分布 相关性 

分 类 号：R58[医药卫生—内分泌]