分娩前产妇凝血四项和D-二聚体及血小板指标联合检测的结果探讨  

Results discussion of combined detection of coagulation four items,D-dimer and platelet indexes in pregnant women before delivery

作　　者：吕青青[1] Lyu Qingqing(Department of Clinical Laboratory,Jinxiang County People's Hospital,Jining 272200,Shandong,China)

机构地区：[1]金乡县人民医院检验科,山东济宁272200

出　　处：《实用检验医师杂志》2024年第4期361-364,共4页Chinese Journal of Clinical Pathologist

摘　　要：目的探讨产妇分娩前凝血四项、D-二聚体及血小板指标联合检测结果,评估产妇凝血相关风险。方法选择金乡县人民医院2022年10月—2023年10月收治的40例临产产妇作为研究对象,纳入观察组;另外选择同期40例在该院行健康体检的非妊娠女性纳入对照组。采用全自动凝血分析仪对所有受检者进行凝血四项〔包括凝血酶时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)〕和D-二聚体检测,采用全自动血液分析仪检测血小板指标〔包括血小板计数(PLT)、平均血小板容积(MPV)〕;分析并比较两组上述指标水平差异。结果观察组的凝血指标TT、PT、APTT水平均显著低于对照组,FIB水平显著高于对照组〔TT(s):12.13±1.05比13.86±1.38;PT(s):10.16±1.26比12.75±1.75;APTT(s):28.08±2.33比31.69±3.56;FIB(g/L):424.63±52.43比274.25±32.28;均P<0.05〕。观察组D-二聚体水平显著高于对照组(μg/L:766.59±44.38比366.69±31.43,P<0.05)。观察组的PLT水平显著低于对照组,MPV水平显著高于对照组〔PLT(×10^(9)/L):172.27±21.32比213.86±25.64;MPV(fL):10.65±1.16比8.86±0.98;均P<0.05〕。结论在产妇分娩前开展凝血四项、D-二聚体以及血小板指标联合检测可以帮助临床医师评估孕妇的凝血功能以及预测在分娩过程中可能出现的凝血相关风险,对临床具有积极的影响。Objective To explore the combined detection results of coagulation four items,D-dimer and platelet indexes before delivery,and evaluate the risk of maternal coagulation of parturients.Methods The 40 parturients admitted to Jinxiang County People's Hospital from October 2022 to October 2023 were selected as research subjects and included in observation group.Additionally,40 non pregnant women undergoing health check-ups during the same period were selected as control group.Using fully automated blood coagulation analyzer,all subjects were tested for coagulation four items[thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)]and D-dimer.Platelet indicators[platelet count(PLT)and mean platelet volume(MPV)]were detected using fully automated blood analyzer.The differences in the levels of above indicators between two groups were analyzed and compared.Results The levels of coagulation indexes TT,PT and APTT were significantly lower than those in control group,and the level of FIB was significantly higher than that in control group[TT(s):12.13±1.05 vs.13.86±1.38;PT(s):10.16±1.26 vs.12.75±1.75;APTT(s):28.08±2.33 vs.31.69±3.56;FIB(g/L):424.63±52.43 vs.274.25±32.28;all P<0.05].The level of D-dimer was significantly higher in observation group than that in control group(μg/L:766.59±44.38 vs.366.69±31.43,P<0.05).The level of PLT in observation group was significantly lower than that in control group,and the level of MPV was significantly higher than that in control group[PLT(×10^(9)/L):172.27±21.32 vs.213.86±25.64;MPV(fL):10.65±1.16 vs.8.86±0.98;both P<0.05].Conclusion The combined detection of coagulation four items,D-dimer and platelet indexes before delivery could help clinicians to evaluate the coagulation function of pregnant women and predict the possible coagulation-related risk during delivery,which has a positive impact on clinical practice.

关 键 词：妊娠 产妇 凝血四项 D-二聚体 血小板 联合检验 

分 类 号：R71[医药卫生—妇产科学]