中藏药防治高原低氧脑损伤作用及机制研究进展  

Research progress on the effect and mechanism of Chinese and Tibetan medicine in preventing and treating high-altitude hypoxia-induced brain injury

作　　者：陈丽萍 王荣 刘菲菲 CHEN Liping;WANG Rong;LIU Feifei(Pharmaceutical Preparation Section,No.940 Hospital of PLA Joint Logistics Surpport Force,Lanzhou,Gansu,730050,China;School of Pharmacy,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China)

机构地区：[1]中国人民解放军联勤保障部队第九四〇医院药剂科,甘肃兰州730050 [2]甘肃中医药大学药学院,甘肃兰州730101

出　　处：《甘肃中医药大学学报》2024年第6期68-76,共9页Journal of Gansu University of Chinese Medicine

基　　金：甘肃省科技计划重大专项(23ZDFA013-5);兰州市科技局项目(2023-2-62);联勤保障部队第九四○医院院内民用科研项目(2021YXKY082,2023YXKY016)。

摘　　要：查阅相关文献,归纳总结近10年单味及复方中藏药防治高原低氧脑损伤作用及机制的研究概况,通过系统地总结和对比各类中藏药的生物活性和作用机制,进一步发掘其治疗高原低氧脑损伤的潜力,为中藏药防治高原低氧脑损伤的临床应用和创新研发提供参考和研究思路。目前中藏药防治高原低氧脑损伤的作用机制研究不够清晰、具体,深层次的研究和探索较少,并且大部分研究还处于动物实验阶段,缺乏大样本的随机对照研究来验证其临床有效性。因此,未来亟需多学科、多技术的交叉融合,以更深入地开展体内外实验研究,这将有助于加速实验结果的临床转化,为药物研发提供更为坚实的实验依据。This paper provides a comprehensive overview of research on the effect and machanism conducted over the past decade on both single-ingredient and compound Tibetan medicine for the prevention and treatment of hypoxia-induced brain injury at high altitudes.By systematically summarizing and comparing the bioactivity and mechanisms of action of various Tibetan and Chinese herbs,this study further explores their potential in addressing hypoxia-induced brain injury in high-altitude environments,thereby offering valuable references and innovative ideas for clinical applications as well as drug development aimed at preventing and treating such injuries.At present,it has been observed that the understanding of the mechanisms by which Tibetan and Chinese herbs prevent or treat hypo-xia-induced brain injury remains unclear and lacks specificity.There is a notable deficiency in thorough research and exploration within this field.Most studies are still confined to animal experiments,with few large-scale randomized controlled trials available to validate their clinical efficacy.Consequently,there is an urgent need for future research to integrate multidisciplinary approaches alongside advanced technological methods to conduct more extensive in vivo and in vitro experiments.This will facilitate the acceleration of clinical translation from experimental findings while providing robust empirical evidence for drug development efforts.

关 键 词：高原低氧脑损伤 中藏药 单味 复方 作用机制 综述 

分 类 号：R285[医药卫生—中药学]