雾化糖皮质激素联合特布他林对慢性阻塞性肺疾病急性加重期合并糖尿病患者血糖与肺功能的影响  

Effect of aerosolized glucocorticoids combined with Terbutaline on blood glucose and pulmonary function in patients with chronic obstructive pulmonary disease exacerbation and diabetes mellitus

作　　者：佟晓妲 陈雷[1] TONG Xiaoda;CHEN Lei(Department of Respiratory and Critical Care Medicine,Central Hospital Affiliated to Shenyang Medical College,Liaoning Province,Shenyang 110024,China)

机构地区：[1]沈阳医学院附属中心医院呼吸与危重症医学科,辽宁沈阳110024

出　　处：《中国当代医药》2025年第2期42-45,共4页China Modern Medicine

摘　　要：目的分析雾化吸入糖皮质激素联合特布他林对慢性阻塞性肺疾病急性加重期合并糖尿病患者血糖与肺功能的影响。方法选取2023年1月至12月沈阳医学院附属中心医院收治的80例慢性阻塞性肺疾病急性加重期合并糖尿病患者作为研究对象,按照计算机随机数法分为观察组(40例)与对照组(40例)。观察组采用雾化吸入糖皮质激素联合特布他林治疗,对照组采用单一特布他林治疗。比较两组患者的血糖、肺功能、不良反应发生情况的差异。结果治疗前,两组患者的第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC比较,差异无统计学意义(P>0.05);观察组FEV_(1)、FVC、FEV_(1)/FVC高于对照组,差异有统计学意义(P<0.05);治疗前,两组患者的动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))比较,差异无统计学意义(P>0.05);观察组PaO_(2)高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05);治疗前,两组患者的空腹血糖、餐后2 h血糖比较,差异无统计学意义(P>0.05);治疗后,两组患者的空腹血糖、餐后2 h血糖低于对照组,差异有统计学意义(P<0.05);观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论慢性阻塞性肺疾病急性加重期合并糖尿病患者采用雾化吸入糖皮质激素联合特布他林作为治疗药物,能够大幅度改善患者肺通气功能,有效控制血糖,减少不良反应的发生。Objective To analyze the effect of aerosolized inhalation of glucocorticoids combined with Terbutaline on blood glucose and pulmonary function in patients with acute chronic obstructive pulmonary disease exacerbation and diabetes mellitus.Methods A total of 80 patients with acute chronic obstructive pulmonary disease exacerbation and diabetes mellitus admitted to Central Hospital Affiliated to Shenyang Medical College from January to December 2023 were selected as research objects and they were divided into observation group(40 cases)and control group(40 cases)according to computer random number method.The observation group was treated with atomized inhaled glucocorticoid combined with Terbutaline,and the control group was treated with Terbutaline alone.The differences of blood glucose,pulmonary function and adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in forced expiratory volume in one second(FEV_(1)),forced vital capacity(FVC)and FEV_(1)/FVC between two groups(P>0.05).FEV_(1),FVC and FEV_(1)/FVC in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in partial pressure of oxygen in arterial blood(PaO_(2))and partial pressure of carbon dioxide in arterial blood(PaCO_(2))between two groups(P>0.05).PaO_(2)in observation group was higher than that in control group,PaCO_(2)was lower than that in control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in fasting blood glucose and 2 h postprandial blood glucose between two groups(P>0.05).After treatment,the fasting blood glucose and 2 h postprandial blood glucose of two groups were lower than those of control group,and the differences were statistically significant(P<0.05).The total inci dence of adverse reactions in observation group was lower than that in control group,and the difference was statistically sign

关 键 词：糖皮质激素 特布他林 慢性阻塞性肺疾病 糖尿病 

分 类 号：R563.9[医药卫生—呼吸系统]