miRNA与慢性阻塞性肺疾病相关性研究进展  

Research progress on the relationship between miRNA and chronic obstructive pulmonary disease

作　　者：王沐雨 刘健[2] 张丹丹[1] 曹苡诚 WANG Muyu;LIU Jian;ZHANG Dandan;CAO Yicheng(Graduate School,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;Department of Respiratory and Critical Care Medicine,the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300143,China)

机构地区：[1]天津中医药大学研究生学院,天津300193 [2]天津中医药大学第二附属医院呼吸与危重症医学科,天津300143

出　　处：《中国医药导报》2024年第36期50-55,74,共7页China Medical Herald

基　　金：国家自然科学基金资助项目(U20A20398)。

摘　　要：慢性阻塞性肺疾病(COPD)是一种以进行性、不可逆气流受限为特征的常见慢性呼吸系统疾病,其发病率、死亡率居高不下。微RNA(miRNA)作为对基因表达具有调节作用的内源性、单链非编码RNA,参与COPD的病理生理过程。香烟烟雾诱导下miRNA的差异性表达及诱导的炎症反应是COPD发病的重要因素,不同miRNA通过不同机制作用于COPD,通过上调或下调可有效调节COPD的生物学过程。同时,miRNA在肺气肿、COPD急性加重期及肺功能中具有差异性表达,可为COPD精准化治疗提供靶点。本文对miRNA与COPD关系的研究进展进行综述。Chronic obstructive pulmonary disease(COPD)is a common chronic respiratory disease characterized by progressive,and irreversible airflow restriction,with high morbidity and mortality.MicroRNA(miRNA)as endogenous,single-stranded non-coding RNA with regulatory effects on gene expression,participates in the pathophysiological processes of COPD.The differential expression of miRNA,and the induced inflammatory response induced by cigarette smoke are important factors in the pathogenesis of COPD.Different miRNAs act on COPD through different mechanisms,and upregulation or downregulation can effectively regulate the biological processes of COPD.At the same time,miRNA is differentially expressed in emphysema,acute exacerbation of COPD,and lung function,which may provide targets for the precise treatment of COPD.This article reviews research progress on the relationship between miRNA and COPD.

关 键 词：慢性阻塞性肺疾病 微RNA 香烟烟雾 炎症 肺气肿 肺功能 

分 类 号：R563[医药卫生—呼吸系统]