缓释型肉桂醛微球的制备及驱蚊活性  

PREPARATION OF SUSTAINED RELEASE CINNAMALDEHYDEMICROSPHERES AND ITS REPELLENT ACTIVITYAGAINST AEDES AEGYPTI

作　　者：余锡辉 吴鹰花 YU Xi-hui;WU Ying-hua(Zhongshan Lanju Daily Chemical Industrial Co.,Ltd,Zhongshan 528400,Guangdong,China)

机构地区：[1]中山榄菊日化实业有限公司科创中心,广东中山528400

出　　处：《寄生虫与医学昆虫学报》2024年第4期203-208,共6页Acta Parasitologica et Medica Entomologica Sinica

基　　金：广东省企业科技特派员专项(GDKTP2021024200)。

摘　　要：目的 延长肉桂醛的驱避时长,增强其驱蚊活性。方法 采用层层自组装法以壳聚糖和明胶为壁材制备肉桂醛微球。通过傅里叶红外光谱仪、扫描电子显微镜、激光粒度仪、紫外分光光度仪以及微孔压电超声雾化器对微球的结构、形貌、粒径、包封率以及雾化效率进行研究。参照国标GB/T 13917.9—2009执行驱蚊药效试验及记录有效保护时间。结果 肉桂醛成功包封,微球呈球形,包封率为65%,平均粒径为1 613.7 nm,雾滴粒径小,雾化量较大,雾滴中径为23.57μm。5%的肉桂醛在第2小时对蚊虫的驱避率低于50%,驱避效果较差。肉桂醛微球在第2小时的驱避率仍有100%,到第4小时驱避率仍保持在82.64%。结论 缓释型肉桂醛微球可减少肉桂醛的气味,同时对埃及伊蚊的驱避时长可达2 h,为开发新型的驱蚊剂提供思路。Objective This study aimed to prolong the duration of cinnamaldehyde's insect repellent activity and enhance its repellent potency.Methods Cinnamaldehyde microspheres were prepared using chitosan and gelatin as wall materials via layered self-assembly.The structure,morphology,particle size,encapsulation rate,and atomization efficiency of the microspheres were investigated using Fourier transform infrared spectrometry,scanning electron microscopy,laser particle size analyses,ultraviolet spectrophotometry,and a micropore piezoelectric ultrasonic atomizer.An efficacy test of the mosquito repellent was performed according to GB/T 13917.9-2009 and the effective protection time was recorded.Results Cinnamaldehyde was successfully encapsulated in spherical microspheres with an encapsulation rate of 65%.The average particle size was 1613.7 nm and the droplet particle size was small.The atomization volume was large,and the middle diameter of the droplets was 23.57μm.The repellent rate of 5%cinnamaldehyde was<50%in the 2nd hour and its repellent efficacy was poor.The repellent rates of the cinnamaldehyde microspheres were 100%in the 2nd hour and 82.64%in the 4th hour.Conclusions Slow-release cinnamaldehyde microspheres can mitigate the olfactory impact of cinnamaldehyde and extend its repellent activity against Aedes aegypti up to 2 h,offering insights into novel enhanced formulations for mosquito repellents.

关 键 词：肉桂醛 微球 驱蚊活性 埃及伊蚊 

分 类 号：R384.3[医药卫生—医学寄生虫学]