丙泊酚与咪达唑仑对重度子痫前期患者术后镇静的效果研究  

Effect of propofol and midazolam on postoperative sedation in patients with severe preeclampsia

作　　者：刘芬 柯汉恒 黄冰 邓梅波 戴云先[1] Liu Fen;Ke Hanheng;Huang Bing;Deng Meibo;Dai Yunxian(Medical Intensive Care Unit,Maoming Maternal and Child Health Hospital,Maoming 525000,China)

机构地区：[1]茂名市妇幼保健院MICU,广东茂名525000

出　　处：《实用妇科内分泌电子杂志》2024年第20期35-37,12,共4页Electronic Journal of Practical Gynecological Endocrinology

基　　金：茂名市科技计划项目(项目编号:2022293)。

摘　　要：目的探讨丙泊酚、咪达唑仑用于重度子痫前期术后镇静的效果。方法选取63例重度子痫前期行剖宫产术者为研究对象,按照随机数字表法分为丙泊酚组(33例,予丙泊酚治疗)、咪达唑仑组(30例,予咪达唑仑治疗)。对比两组患者的镇静起效时间、镇静深度及生命体征。结果丙泊酚组镇静起效时间为(22.72±6.87)min,短于咪达唑仑组的(31.20±8.49)min;镇静深度为(3.23±0.45)级,高于咪达唑仑组的(2.65±0.38)级,差异均有统计学意义(P<0.05)。丙泊酚组用药1 h、2 h的呼吸频率均低于咪达唑仑组,用药2 h、6 h、12 h的脉搏均低于咪达唑仑组,差异均有统计学意义(P<0.05)。两组各时点的收缩压与舒张压比较,差异无统计学意义(P>0.05)。结论丙泊酚在重度子痫前期剖宫产术后镇静中的应用效果满意,其镇静深度好,相比咪达唑仑能更好地维持患者术后生命体征稳定,值得临床推广使用。Objective To investigate the effect of propofol and midazolam on postoperative sedation of severe preeclampsia.Methods 63 patients who underwent cesarean section for severe preeclampsia were selected as the study subjects and divided into the propofol group(33 cases)and the midazolam group(30 cases)according to random number table method.The onset time,depth of sedation and vital signs of the two groups were compared.Results The onset time of sedation in the propofol group was(22.72±6.87)min,which was shorter than(31.20±8.49)min in the midazolam group,and the score of sedation depth was(3.23±0.45)points,which was higher than(3.23±0.45)points in the midazolam group(P<0.05).The respiratory rates of the propofol group were lower than those of the midazolam group after 1 h and 2 h of medication,and the pulse rates were lower than those of the midazolam group after 2 h,6 h and 12 h of medication(P<0.05).There were no significant differences in the systolic and diastolic blood pressure levels between the two groups at each time point(P>0.05).Conclusion The application of propofol in sedation after caesarean section of severe preeclampsia is satisfactory,and its sedation depth is good,compared with midazolam,which can better maintain the stability of postoperative vital signs,worthy of clinical promotion.

关 键 词：重度子痫前期 丙泊酚 咪达唑仑 剖宫产 镇静 

分 类 号：R71[医药卫生—妇产科学]