和厚朴酚与厚朴酚治疗免疫紊乱疾病及其免疫调控作用研究进展  

Research progress on treatment of immune-disordered diseases and their immunomodulatory effects by honokiol and magnolol

作　　者：秦晓颖 陈文静[1,2] 刘玉萍 张黄琴[1,3] 陈彦 QIN Xiaoying;CHEN Wenjing;LIU Yuping;ZHANG Huangqin;CHEN Yan(Affiliated Hospital of Integrated Traditional Chinese Medicine,Nanjing University of Chinese Medicine,Nanjing 210028,China;Multicomponent of Traditional Chinese Medicine and Microecology Research Center,Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China;State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture,Nanjing University of Chinese Medicine,Nanjing 210023,China)

机构地区：[1]南京中医药大学附属中西医结合医院,江苏南京210028 [2]江苏省中医药研究院中药组分与微生态研究中心,江苏南京210028 [3]南京中医药大学中药制药过程控制与智能制造技术全国重点实验室,江苏南京210023

出　　处：《中草药》2024年第24期8602-8612,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(82374045);江苏省中医药领军人才项目(CZ2023SLJ0302);江苏省中医药科技发展计划青年人才项目(QN202213);江苏省中医消化道肿瘤临床创新中心项目(2021.6)。

摘　　要：和厚朴酚与厚朴酚是传统中药厚朴中的双酚类活性成分,具有抗菌、抗炎、抗氧化、抗肿瘤、神经保护等药理活性。近年来,研究证实和厚朴酚与厚朴酚可作为潜力巨大的免疫调节剂用于感染性疾病、自身免疫疾病(过敏性哮喘、溃疡性结肠炎、系统性红斑狼疮、类风湿性关节炎等)和癌症的治疗。通过综述和厚朴酚与厚朴酚在免疫紊乱疾病(脓毒症、自身免疫疾病)和肿瘤中的研究进展和其发挥免疫调控作用的主要分子机制,并简介和厚朴酚与厚朴酚纳米制剂的应用,为和厚朴酚与厚朴酚在免疫失调疾病中的进一步临床应用和开发提供理论指导和思路。Honokiol and magnolol are bisphenol active ingredients in traditional Chinese medicine Houpo(Magnoliae Officinalis Cortex),which have various pharmacological activities such as antibacterial,anti-inflammatory,antioxidant,antitumor and neuroprotective properties.Recent studies have confirmed that honokiol and magnolol can be used as potential immune modulators for the treatment of infectious diseases,autoimmune diseases(such as allergic asthma,ulcerative colitis,systemic lupus erythematosus,rheumatoid arthritis,etc.)and cancer.This review summarizes the research progress of honokiol and magnolol in immune disorders(sepsis,autoimmune diseases)and cancers,and main molecular mechanisms of their immune regulatory effects.It also briefly introduces the application of nano-formulations of honokiol and magnolol,hoping to provide theoretical guidance and ideas for the further clinical application and development of honokiol and magnolol in immune disorders.

关 键 词：和厚朴酚 厚朴酚 免疫调节 自身免疫疾病 肿瘤免疫 抗菌 抗炎 神经保护 

分 类 号：R285[医药卫生—中药学]