基于斑马鱼模型的中药抗肿瘤研究进展  

Research progress on antitumor of traditional Chinese medicine based on zebrafish model

作　　者：梁沁沁 黎欣 张冰月 夏中尚 张帆 郝二伟 邓家刚 侯小涛 LIANG Qinqin;LI Xin;ZHANG Bingyue;XIA Zhongshang;ZHANG Fan;HAO Erwei;DENG Jiagang;HOU Xiaotao(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Key Laboratory of TCM Formulas Theory and Transformation for Damp Disease,University Engineering Research Center of Reutilization of Traditional Chinese Medicine Resources of Guangxi,Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,广西南宁530200 [2]广西中医药大学广西中药药效研究重点实验室,中药资源循环利用广西高校工程研究中心,广西中医湿病方药理论与转化重点实验室,广西南宁530200

出　　处：《中草药》2024年第24期8644-8653,共10页Chinese Traditional and Herbal Drugs

基　　金：广西自然科学基金项目(2020GXNSFBA159020);引进博士科研启动基金项目(2022BS022);广西中医药大学“桂派中医药传承创新团队”(2022A005)。

摘　　要：恶性肿瘤是全球主要死亡原因之一,随着其发病率和死亡率的逐年攀升,关于其发病机制、进展过程、新药开发等相关研究亟待推进。中药在预防和治疗肿瘤中表现出极好的临床效果和前景。斑马鱼因与人类基因高度相似、胚胎和幼体透明、繁殖能力强、研究周期短、成本低等特性而备受青睐,已被用于多种肿瘤的研究。通过对近十年国内外斑马鱼肿瘤模型的特征及其在中药治疗肺癌、结直肠癌、肝癌、乳腺癌和胃癌研究中的应用进展进行综述,为实验建模提供新的思路和方法,为新药研发提供参考。Malignant tumors are one of the main causes of death in the world,and with their morbidity and mortality increasing year by year,a series of related studies on their pathogenesis,progress and new drug development need to be advanced.Traditional Chinese medicine has shown excellent clinical effects and prospects in the prevention and treatment of tumors.Zebrafish is favored by researchers because of its high genetic similarity to humans,transparent embryos and larvae,strong reproductive ability,short study cycle,and low cost,and has been used in the study of a variety of tumors.In this paper,the characteristics of zebrafish tumor models and their application in treatment of lung cancer,colorectal cancer,liver cancer,breast cancer and gastric cancer have been reviewed in recent ten years,to provide new ideas and methods for experimental modeling and provide references for the development of new drugs.

关 键 词：斑马鱼 肿瘤 模型 中药 中药单体 中药复方 

分 类 号：R285[医药卫生—中药学]