关黄柏抗肿瘤活性成分及其作用机制研究进展  

Research progress on antitumor bioactive compounds and mechanisms of Phellodendri Amurensis Cortex

作　　者：白洛宁 李先娜[1] 孙晖[1] 闫广利[1] 孔玲[1] 韩莹[1] 王喜军[1] BAI Luoning;LI Xianna;SUN Hui;YAN Guangli;KONG Ling;HAN Ying;WANG Xijun(State Key Laboratary of Integration and Innovation of Classic Formula and Modern Chinese Medicine,Chinmedomics Research Center of National Administration of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,经方与现代中药融合创新全国重点实验室,国家中医药管理局中医方证代谢组学研究中心,黑龙江哈尔滨150040

出　　处：《中草药》2024年第24期8664-8677,共14页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金青年科学基金项目(82204690);中国博士后科学基金第17批特别资助项目(2024T170257);黑龙江省自然科学基金联合引导项目(LH2023H069);黑龙江省中医药经典普及化研究专项课题(ZYW2022-065);2022年度黑龙江省省属高等学校基本科研业务费科研项目(2022PT03);2022年度省教育科学规划重点课题(GJB1422248);黑龙江中医药大学科研基金项目(青年科技创新能力培养计划)(2024XJJ-QNCX012)。

摘　　要：关黄柏源于芸香科植物黄檗Phellodendron amurense的干燥树皮,具有清热燥湿、泻火解毒等功效。现代研究表明,关黄柏中主要含有生物碱类、萜类、内酯类、黄酮类等多种化合物,其中小檗碱、木兰碱、黄柏内酯等成分展现出显著的抗炎、抗肿瘤及免疫调节活性,对前列腺癌、肺癌、肝癌、乳腺癌等恶性肿瘤细胞具有诱导自噬与凋亡,抑制增殖、迁移和侵袭,阻滞细胞周期,调节代谢,提高机体免疫功能等多重作用。通过对国内外文献进行整合分析,筛选关黄柏抗肿瘤活性成分,阐明其抗肿瘤作用机制,为关黄柏在抗肿瘤领域的开发应用提供参考借鉴,助力临床抗癌新药研发。Guanhuangbai(Phellodendri Amurensis Cortex)is derived from the dried bark of the Rutaceae plant Phellodendron amurense Rupr.It has the functions of clearing away heat and dampness,purging fire and detoxifying.Recent studies have demonstrated that Phellodendri Amurensis Cortex mainly contains alkaloids,terpenoids,lactones,flavonoids and other compounds,among which berberine,magnoflorine,obaculactone and other components show significant anti-inflammatory,antitumor and immunomodulatory activities.These compounds exhibit multiple effects,including inducing autophagy and apoptosis,inhibiting proliferation,migration and invasion,arresting the cell cycle,regulating metabolism and improving immune function of malignant tumor cells such as prostate cancer,lung cancer,liver cancer and breast cancer.Based on a comprehensive review of domestic and international literature,the antitumor active components of Phellodendri Amurensis Cortex were screened,and its anti-tumor mechanism was clarified,so as to provide a reference for the development and application of Phellodendri Amurensis Cortex in the anti-tumor field and aid the clinical development of new anticancer drugs.

关 键 词：关黄柏 抗肿瘤 小檗碱 巴马汀 木兰碱 黄柏内酯 

分 类 号：R285[医药卫生—中药学] R284[医药卫生—中医学]