非编码RNA靶点药物支架开发研究进展  

Research progress in the development of ncRNA-targeted drug scaffolds

作　　者：窦文朝 彭瑜[2,3] 张钲 DOU Wen-chao;PENG Yu;ZHANG Zheng(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Heart Center,the First Hospital of Lanzhou University,Lanzhou 730000,China;Gansu Provincial Clinical Research Center for Cardiovascular Diseases,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,甘肃兰州730000 [2]兰州大学第一医院心脏中心,甘肃兰州730000 [3]甘肃省心血管病临床医学研究中心,甘肃兰州730000

出　　处：《中国介入心脏病学杂志》2025年第1期42-46,共5页Chinese Journal of Interventional Cardiology

摘　　要：经皮冠状动脉介入治疗(PCI)是当今冠状动脉疾病(CHD)的主要治疗方法。支架内再狭窄(ISR)的特征是支架内进行性管腔狭窄,这与PCI对于血管机械损伤引起的血管炎症、血小板活化、血管平滑肌细胞(VSMC)增殖和迁移以及细胞外基质重塑等相关。内皮细胞生长能愈合被支架损坏的血管内层,并防止血栓形成,而药物洗脱支架(DES)置入会在抑制VSMC增殖的同时,抑制靶病变处所有细胞的生长,这一问题亟待解决。目前,有研究表明一些围绕非编码RNA及相关的表观遗传通路开发的药物通过支架递送能够靶向抑制VSMC增殖,而不影响血管内膜再内皮化,促进血管内膜愈合。因此,本综述探讨了非编码RNA药物支架开发及相关临床试验的研究进展,以确定其在解决DES临床应用带来的相关问题的可行性。Percutaneous coronary intervention(PCI)is the main treatment for coronary heart disease(CHD).is characterized by progressive lumen stenosis in the stent,which is related to the effect of PCI on vascular inflammation,platelet activation,smooth muscle cell proliferation and migration,and extracellular matrix remodeling caused by vascular mechanical injury.Endothelial cell(EC)growth can heal the vascular lining damaged by the stent and prevent thrombosis,while drug eluting stent(DES)implantation inhibits the proliferation of vascular smooth muscle cells(VSMC)while inhibiting the growth of all cells at the target lesion.At present,some studies have shown that some drugs developed around non-coding RNA and related epigenetic pathways can target and inhibit VSMC proliferation through scaffold delivery,without affecting vascular intimal reendothelialization and promoting vascular intimal healing.Therefore,this review reviews the research progress of non-coding RNA drug scaffolds development and related clinical trials to determine their feasibility in solving the problems related to the clinical application of DES.

关 键 词：经皮冠状动脉介入治疗 支架内再狭窄 非编码RNA药物支架 血管平滑肌细胞 内皮细胞 血栓形成 

分 类 号：R5[医药卫生—内科学]