壮医药线升阳灸对失眠患者睡眠质量及相关生物标志物的影响  

Effects of Zhuang medicine Yang-rising medicated thread moxibustion on sleep quality and related biomarkers in insomnia patients

作　　者：潘明甫 贺诗寓 罗远带 龙炜 PAN Mingfu;HE Shiyu;LUO Yuandai;LONG Wei(International Zhuang Medicine Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学附属国际壮医医院,南宁530200

出　　处：《吉林中医药》2025年第1期113-116,共4页Jilin Journal of Chinese Medicine

基　　金：广西壮族自治区中医药管理局中医药学术传承试点基金项目(GXZYYXS-202302);广西壮族自治区中医药管理局广西中医药重点学科建设项目(GZXK-Z-20-60)。

摘　　要：目的观察壮医药线升阳灸治疗失眠患者的临床疗效及对睡眠相关生物标志物的影响。方法选择原发性失眠患者120例,随机分为壮医组与对照组,各60例,壮医组采用药线升阳灸治疗,对照组采用百会传统灸法治疗,每日2次,记录2组PSQI睡眠指数、中医证候积分,检测2组5-HT、GABA、乙酰胆碱水平。结果治疗后,壮医组PSQI指数、中医证候积分均下降(P<0.05),5-HT、GABA上升(P<0.05),乙酰胆碱下降(P<0.05),差异均具有统计学意义;对照组PSQI下降(P<0.05),5-HT上升(P<0.05),中医证候积分下降,差异无统计学意义(P>0.05),GABA、乙酰胆碱无明显变化。壮医组PSQI、中医证候积分、5-HT、GABA、乙酰胆碱水平变化均优于对照组(P<0.05)。2组均无严重不良事件发生。结论壮医药线升阳灸能够有效改善原发性失眠患者的睡眠质量和临床症状,调节睡眠相关生物标志物水平,且安全有效。Objective To observe the clinical efficacy of Zhuang medicine Yang-rising medicated thread moxibustion in the treatment of insomnia patients and its effects on sleep-related biomarkers.Methods A total of 120 patients with primary insomnia treated from December 2020 to December 2022 were randomly divided into a Zhuang medicine group(60 cases)and a control group(60 cases).The Zhuang medicine group was treated with Yang-rising medicated thread moxibustion,while the control group was treated with conventional moxibustion at Baihui(GV 20),twice a day.Their effect was evaluated by recording the PSQI scores and TCM syndrome scores in the two groups,while their effects on biomarkers were observed by detecting the level changes of 5-HT,GABA and acetylcholine.Results After treatment,the PSQI scores and TCM syndrome scores of the Zhuang medicine group decreased,while the levels of 5-HT and GABA increased,and the level of acetylcholine decreased,all with a statistically significant difference(P<0.05).The control group showed a decrease in PSQI scores(P<0.05),an increase in the level of 5-HT(P<0.05),a decrease in TCM syndrome scores,yet with no statistically significant difference(P>0.05),and there were no significant changes in the levels of GABA and acetylcholine.The comparison between the two groups showed that the changes in the PSQI scores,TCM syndrome scores,levels of 5-HT,GABA and acetylcholine in the Zhuang medicine group were significantly better than those in the control group(P<0.05).There were no serious adverse events in both groups.Conclusion The treatment of primary insomnia patients with Zhuang medicine Yang-rising medicated thread moxibustion can effectively improve their sleep quality and clinical symptoms,regulate the levels of sleep-related biomarkers,and is safe and effective.

关 键 词：壮医 睡眠障碍 5-羟色胺 Γ-氨基丁酸 乙酰胆碱 

分 类 号：R245.8[医药卫生—针灸推拿学]