Prospective 12‑month outcomes of combined iStent inject implantation and phacoemulsification in Asian eyes with normal tension glaucoma  

作　　者：Bryan Chin Hou Ang Wenqi Chiew Vivien Cherng Hui Yip Chun Hau Chua Wei Shan Han Ivan O’Neill CTecson Jeanne Joyce Ogle Boon Ang Lim Owen Kim Hee Elton Lik Yong Tay Vernon Khet Yau Yong Hon Tym Wong Leonard Wei Leon Yip 

机构地区：[1]National Healthcare Group Eye Institute,Tan Tock Seng Hospital,Singapore,Singapore [2]National Healthcare Group Eye Institute,Woodlands Health Campus,Singapore,Singapore [3]Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore [4]Cardinal Santos Medical Centre,Manila,Philippines [5]Hesed Eye Specialists,Singapore,Singapore

出　　处：《Eye and Vision》2024年第6期1-11,共11页眼视光学杂志(英文)

摘　　要：Background:Glaucoma is the leading cause of irreversible blindness.Normal tension glaucoma(NTG)is a subset of open-angle glaucoma,demonstrating glaucomatous optic nerve damage in the absence of raised intraocular pressure(IOP).NTG is more prevalent in Asian populations.While generally slow-progressing,NTG may be associated with significant central visual field loss.In recent years,minimally invasive glaucoma surgery has been added to the armamentarium of glaucoma surgery.This prospective study aims to evaluate 12-month surgical outcomes of combined iStent inject(Glaukos Corporation,Laguna Hills,CA)implantation and phacoemulsification in Asian eyes with NTG.Methods:This is a prospective,single-centre case series of 30 eyes followed up until 12 months after surgery.Outcome measures included IOP,number of glaucoma medications,best-corrected visual acuity(BCVA)and intra and postoperative complications.Results:Mean age of subjects was 73.1±6.3 years.Majority were ethnic Chinese(n=27,90%).Baseline medicated mean IOP was 13.8±2.4 mmHg and mean number of glaucoma medications was 1.3±0.7.Mean Humphrey visual field mean deviation was−13.7±7.6.The mean IOP reduction at all timepoints from postoperative month(POM)3 onwards was statistically significant(all P<0.05),with mean reduction of 1.2 mmHg(95%CI:0.1–2.2,P=0.037)by POM12.There was statistically significant reduction in mean number of medications from postoperative day(POD)1 onwards(all P<0.05),with mean decrease of 1.0 medication(95%CI:0.9–1.1,P<0.001)by POM12.By POM12,25(83.3%)eyes were medication-free.Three(10%)eyes had stent occlusion by iris requiring laser iridoplasty.One eye had gross hyphema which resolved on conservative management before POM1.Mean BCVA improved from the baseline 0.3±0.3 logMAR to 0.1±0.1 logMAR postoperatively(P<0.001).There were no major adverse or sight-threatening events.No eyes required further glaucoma surgery during the 12-month follow-up period.Conclusion:Asian eyes with NTG which underwent combined iStent inject implantation

关 键 词：iStent inject Normal tension glaucoma Minimally invasive glaucoma surgery ASIAN 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]