Harnessing traditional herbal medicine:molecular insights into diabetic wound healing for modern therapeutics  

传统草药的运用:为糖尿病伤口愈合提供现代治疗的分子见解

作　　者：Pavithra Bharathy Punniyakoti Veeraveedu Thanikachalam 

机构地区：[1]Department of Pharmaceutics,Saveetha College of Pharmacy,Saveetha Institute of Medical and Technical Sciences(SIMATS),Saveetha University,Thandalam,Chennai 602105,India [2]Department of Pharmaceutical Chemistry,Saveetha College of Pharmacy,Saveetha Institute of Medical and Technical Sciences(SIMATS),Saveetha University,Thandalam,Chennai 602105,India

出　　处：《Digital Chinese Medicine》2024年第4期388-404,共17页数字中医药(英文)

摘　　要：This study aims to explore the molecular aspects of the wound-healing potential of medicinal plants through preclinical and clinical research.This review focuses on the theoretical sup-port and therapeutic effects of traditional herbal plants,herbal formulations,and active com-pounds in herbal medicine.It provides new insights into the management of diabetic wound healing with herbal medicine.A comprehensive literature review was conducted using key-words such as“herbal remedies”“diabetics”“wounds”“bioactive”“medicinal plant”and“growth factor”across several literature databases,namely,Wiley Online Library,Elsevier,Springer,PubMed,and Google Scholar.The available literature provides a basis for tradition-al remedies found to be effective in healing wounds by targeting key molecules involved in wound pathology,including collagen I&III,vascular endothelial growth factor(VEGF),tu-mor necrosis factor-alpha(TNF-α),nuclear factor kappa B(NF-κB),transforming growth fac-tor(TGF)-β1,hydroxyproline(collagen component),superoxide dismutase(SOD),and Cata-lase(CAT).Numerous studies have investigated the presence of bioactive compounds in many plants for their wound-healing effects.The results underscore the potential of various plants in wound healing,highlighting the need for further pharmacological research before clinical application.These findings support the conventional use of herbal remedies and pro-vide the basis for future research into the development of new therapeutic alternatives for wound healing.本研究旨在通过临床前和临床研究探讨药用植物伤口愈合潜力的分子机制。本综述聚焦传统草药植物、草药制剂和草药中的活性化合物的理论基础和疗效,为运用草药治疗糖尿病伤口愈合提供了新的见解。通过检索“草药疗法”“糖尿病患者”“伤口”“生物活性”“药用植物”和“生长因子”等关键词,我们在Wiley Online Library、Elsevier、Springer、PubMed和Google Scholar等多个文献数据库中进行了全面的文献综述。现有文献为传统疗法提供了基础,这些疗法通过靶向伤口病理中涉及的关键分子,包括胶原蛋白I&III、血管内皮生长因子(VEGF)、肿瘤坏死因子α(TNF-α)、核因子κB(NF-κB)、转化生长因子β1(TGF-β1)、羟脯氨酸(胶原蛋白成分)、超氧化物歧化酶(SOD)和过氧化氢酶(CAT)来有效愈合伤口。许多研究探索了多种植物中的生物活性化合物及其伤口愈合效果。研究结果强调了各种植物在伤口愈合中的潜力,突出了在临床应用之前进行进一步药理学研究的必要性。这些发现支持了传统草药疗法的使用,并为未来研究研发新的伤口愈合治疗替代方案提供了基础。

关 键 词：Herbal remedies Diabetic wound healing Pharmacological studies Vascular endothelial growth factor(VEGF) Tumor necrosis factor(TNF)-α Nuclear factor kappa B(NF-κB) Transforming growth factor(TGF)-β1 HYDROXYPROLINE 

分 类 号：R28[医药卫生—中药学]