Uric acid-lowering activity and mechanisms of Chinese medicines with medicinefood homology:a systematic study  

药食同源中药降尿酸活性及其作用机制的系统研究

作　　者：QIN Fengyi ZHU Yishuo ZHAO Lewei CHEN Siyu QING Zhixing 秦枫怡;朱益硕;赵乐威;陈思雨;卿志星(湖南农业大学动物医学院,湖南长沙410128;长沙长徐生物科技有限公司,湖南长沙410199)

机构地区：[1]College of Veterinary Medicine,Hunan Agricultural University,Changsha,Hunan 410128,China [2]Changsha Changxu Biotechnology Ltd.,Changsha,Hunan 410199,China

出　　处：《Digital Chinese Medicine》2024年第4期405-418,共14页数字中医药(英文)

基　　金：National Key R&D Program of China(2021YFD 1600301 and 2021YFD1600105);Hunan Provincial Key Research and Development Project(2023NK2041).

摘　　要：Objective To summarize the uric acid-lowering effects and mechanisms of Chinese medicines with medicine-food homology,aiming to provide novel perspectives for the devel-opment of new anti-hyperuricemia(HUA)drugs.Methods Papers on the research of HUA prevention and treatment with medicine-food ho-mology from December 15,2002 to August 10,2024 were screened and collected through Chi-na National Knowledge Infrastructure(CNKI),PubMed,ScienceDirect,and Google Scholar.Subsequently,the impact of these medications and their extracts,as well as the active com-pounds on HUA were assessed.Results A total of 148 relevant papers were collected,including 43 kinds of Chinese medicines and 61 active compounds,all of which have anti-HUA activity.Among them,41 kinds of Chinese medicines could inhibit the activity of xanthine oxidase,thus leading to the inhibition of uric acid production;and 22 kinds of Chinese medicines could facilitate uric acid excretion,while 15 kinds of Chinese medicines could reduce the inflammation levels in the body and promoting renal protection.Notably,polyphenols and flavonoids are the key active components for the uric acid-lowering effects.Conclusion This study systematically summarized and analyzed the uric acid-lowering ef-fects and mechanisms of Chinese medicines with medicine-food homology,laying a founda-tion for their development as HUA agents.目的通过总结具有药食同源性中药的降尿酸作用与机制,为高尿酸血症(HUA)治疗药物的研发提供新的思路。方法本文通过中国知网(CNKI)、PubMed、ScienceDirect、谷歌学术等平台筛选收集2002年12月15日至2024年8月10日期间关于药食同源中药防治HUA研究的相关文献。随后,评估这些中药及其提取物以及活性化合物对HUA的影响。结果共收集相关文献148篇,包括具有抗HUA活性的43种中药和61种活性化合物。其中41种中药均能够抑制黄嘌呤氧化酶活性,从而抑制尿酸生成;22种中药有助于尿酸排泄;15种中药可降低机体炎症水平,起到肾脏保护的作用。值得注意的是,多酚类和黄酮类化合物是降尿酸的关键活性成分。结论本研究系统分析总结了药食同源中药的降尿酸作用及其机制,为其作为治疗HUA药物的研发奠定基础。

关 键 词：Hyperuricemia(HUA) Medicine food homology Chinese medicine Active compounds EXTRACT 

分 类 号：R58[医药卫生—内分泌]